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EnglishThe insulin receptor substrate-1 (IRS-1) gene has been considered a candidate for insulin resistance, type 2 diabetes, and coronary artery disease. To investigate the relationship between the common Gly(972)Arg IRS-1 variant and the presence of cardiovascular risk factors, 153 glucose-tolerant, unrelated offspring of type 2 diabetic patients were studied. There were no differences between Arg(972) IRS-1 carriers and noncarriers in age, gender, body mass index, waist/hip ratio, body composition, fasting glucose and insulin levels, and glucose or insulin levels during the oral glucose tolerance test. Insulin sensitivity, assessed by hyperinsulinemic-euglycemic clamp, was significantly reduced in carriers of Arg(972) IRS-1 (P < 0.03). Carriers of Arg(972) IRS-1 displayed many features of the insulin resistance syndrome, including higher values for serum triglycerides (P < 0.01), total/high density lipoprotein cholesterol ratio (P < 0.01), free fatty acid levels (P < 0.04), systolic blood pressure (P < 0.04), microalbuminuria (P < 0.003), and intima-media thickness (P < 0.02). These results suggest that the Arg(972) IRS-1 variant could contribute to the risk for atherosclerotic cardiovascular diseases associated with type 2 diabetes by producing a cluster of insulin resistance-related metabolic abnormalities.
Marini, M.A., Frontoni, S., Mineo, D., Bracaglia, D., Cardellini, M., De Nicolais, P., et al. (2003). The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 88(7), 3368-3371.
| Tipologia: | Articolo su rivista |
| Citazione: | Marini, M.A., Frontoni, S., Mineo, D., Bracaglia, D., Cardellini, M., De Nicolais, P., et al. (2003). The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 88(7), 3368-3371. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna Settore BIO/12 Settore MED/13 - Endocrinologia Settore M-EDF/01 - Metodi e Didattiche delle Attivita' Motorie Settore MED/49 - Scienze Tecniche Dietetiche Applicate |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1210/jc.2002-021716 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | lug-2003 |
| Titolo: | The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients |
| Autori: | |
| Autori: | Marini, MA; Frontoni, S; Mineo, D; Bracaglia, D; Cardellini, M; De Nicolais, P; Baroni, A; D'Alfonso, R; Perna, M; Lauro, D; Federici, M; Gambardella, S; Lauro, R; Sesti, G |
| Appare nelle tipologie: | 01 - Articolo su rivista |
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