Severe asthma and long-term Benralizumab effectiveness in real-life

objective: long-term efficacy of benralizumab in real life is not clearly known. we assessed the long-term effectiveness persistence to anti-IL-5R treatment in a group of severe eosinophilic asthmatics. patients and methods: we retrospectively analyzed 95 individuals affected by severe asthma (36 males  ̶ 37.9%; mean age 58.1 ± 12.2) treated with benralizumab (mean time 19.7 ± 7.2 months, range 12-35). outcomes were evaluated at the beginning and at the end of patients' treatment periods. results: mean baseline blood eosinophils were 897.5 ± 720.1 cells/μL (11 ± 5.6%) decreasing to 7.4 ± 20.6 cells/μL (0.97 ± 0.26%; p < 0.0001) after benralizumab. FENO likewise decreased from 63.9 ± 68.4 to 28.4 ± 23.6 ppb, while FEV1% significantly improved (p < 0.0001). mean FEF25-75 also increased from 45.8 ± 24.6% to 60.7 ± 24.6%, whereas RAW dropped from 202.15 ± 109.6% to 135.2 ± 54.75% (p < 0.0001). also, lung volumes greatly decreased. ACT/ACQ significantly improved, while exacerbations number fell from 4.1 ± 2.4, before anti-IL-5R, to 0.33 ± 0.77, after treatment (p < 0.0001). rhinitis severity levels and SNOT-22 also changed favorably. patients that took long-term OCs were 71.6% before treatment, decreasing to 23.2% after benralizumab (p < 0.0001), with an OCs dose reduction from 14.8 ± 8.9 to 1.45 ± 2.8 mg/day (p < 0.0001). 51.6% of subjects used SABA as needed before Benralizumab, falling to 4.2% after treatment. several patients showed a reduction of ICS doses, SABA use and maintenance therapy step-down. clinical/biological response with anti-IL-5R remained constant or even improved in terms of exacerbations or maintenance therapy reductions over time. on the contrary, FEF25-75% improvement slowed down in the long-term. no relationship was found between baseline blood eosinophil number and therapeutic response. conclusions: long-term benralizumab effectiveness persistence in all outcomes in real life was confirmed.