Organic semiconductors are promising for interfacing with biological systems because they are biocompatible, printable and their optical properties tuned. We developed a bio-photoelectrolytic platform based on semiconducting polymer thin films, onto which neuroblastoma SH-SY5Y cells were cultured immersing both in an aqueous biological medium. It was possible to inhibit cell proliferation by 50% in this cancer cell line by subjecting the platform to a series of light pulses over time. Light stimulation was found to increase the concentration of calcium ions inside the cells by three times. The platform also enabled to measure bio-electrical signals. The bio-photoelectrolytic platform and the effective use of light stimulation may open new avenues for in vitro light control/manipulation of cell behaviour, for the development of future novel non-invasive tools for application in biosensing, regenerative medicine and cell-based therapy, and for cancer progression control and therapy.
Ciocca, M., Marcozzi, S., Mariani, P., Lacconi, V., Carlo, A.d., Cinà, L., et al. (2023). A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses. ??????? it.cilea.surplus.oa.citation.tipologie.CitationProceedings.prensentedAt ??????? 18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023, Paestum [10.1109/NMDC57951.2023.10344066].
A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses
Ciocca, M.;Marcozzi, S.;Mariani, P.;Lacconi, V.;Camaioni, A.
;Brown, T. M.
2023-10-22
Abstract
Organic semiconductors are promising for interfacing with biological systems because they are biocompatible, printable and their optical properties tuned. We developed a bio-photoelectrolytic platform based on semiconducting polymer thin films, onto which neuroblastoma SH-SY5Y cells were cultured immersing both in an aqueous biological medium. It was possible to inhibit cell proliferation by 50% in this cancer cell line by subjecting the platform to a series of light pulses over time. Light stimulation was found to increase the concentration of calcium ions inside the cells by three times. The platform also enabled to measure bio-electrical signals. The bio-photoelectrolytic platform and the effective use of light stimulation may open new avenues for in vitro light control/manipulation of cell behaviour, for the development of future novel non-invasive tools for application in biosensing, regenerative medicine and cell-based therapy, and for cancer progression control and therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
