Organic semiconductors are promising for interfacing with biological systems because they are biocompatible, printable and their optical properties tuned. We developed a bio-photoelectrolytic platform based on semiconducting polymer thin films, onto which neuroblastoma SH-SY5Y cells were cultured immersing both in an aqueous biological medium. It was possible to inhibit cell proliferation by 50% in this cancer cell line by subjecting the platform to a series of light pulses over time. Light stimulation was found to increase the concentration of calcium ions inside the cells by three times. The platform also enabled to measure bio-electrical signals. The bio-photoelectrolytic platform and the effective use of light stimulation may open new avenues for in vitro light control/manipulation of cell behaviour, for the development of future novel non-invasive tools for application in biosensing, regenerative medicine and cell-based therapy, and for cancer progression control and therapy.

Ciocca, M., Marcozzi, S., Mariani, P., Lacconi, V., Carlo, A.d., Cinà, L., et al. (2023). A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses. ??????? it.cilea.surplus.oa.citation.tipologie.CitationProceedings.prensentedAt ??????? 18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023, Paestum [10.1109/NMDC57951.2023.10344066].

A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses

Ciocca, M.;Marcozzi, S.;Mariani, P.;Lacconi, V.;Camaioni, A.
;
Brown, T. M.
2023-10-22

Abstract

Organic semiconductors are promising for interfacing with biological systems because they are biocompatible, printable and their optical properties tuned. We developed a bio-photoelectrolytic platform based on semiconducting polymer thin films, onto which neuroblastoma SH-SY5Y cells were cultured immersing both in an aqueous biological medium. It was possible to inhibit cell proliferation by 50% in this cancer cell line by subjecting the platform to a series of light pulses over time. Light stimulation was found to increase the concentration of calcium ions inside the cells by three times. The platform also enabled to measure bio-electrical signals. The bio-photoelectrolytic platform and the effective use of light stimulation may open new avenues for in vitro light control/manipulation of cell behaviour, for the development of future novel non-invasive tools for application in biosensing, regenerative medicine and cell-based therapy, and for cancer progression control and therapy.
18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023
Paestum
2023
195404
Rilevanza internazionale
contributo
22-ott-2023
Settore ING-INF/01
Settore BIO/17
English
Biocompatibility; Cell culture; Cell proliferation; Diseases; Light transmission; Polymer films; Light pulse; Light stimulation; Living cell; Measurement and control; Neuroblastomas; Polymer thin films; SH SY5Y Cells
Intervento a convegno
Ciocca, M., Marcozzi, S., Mariani, P., Lacconi, V., Carlo, A.d., Cinà, L., et al. (2023). A Bio-photoelectrolytic Organic Semiconductor Platform For Measurement And Control Of Proliferation And Behaviour Of Living Cells Using Light Pulses. ??????? it.cilea.surplus.oa.citation.tipologie.CitationProceedings.prensentedAt ??????? 18th IEEE Nanotechnology Materials and Devices Conference, NMDC 2023, Paestum [10.1109/NMDC57951.2023.10344066].
Ciocca, M; Marcozzi, S; Mariani, P; Lacconi, V; Carlo, Ad; Cinà, L; Rosato-Siri, Md; Zanon, A; Cattelan, G; Avancini, E; Lugli, P; Priya, S; Camaioni...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/351323
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