the polyphenols curcumin (CUR) and resveratrol (RES) are widely described for their antitumoral effects. however, their low bioavailability is a drawback for their use in therapy. the aim of this study was to explore whether CUR and RES, used at a bioavailable concentration, could modulate immune responses while retaining antitumor activity and to determine whether CUR and RES effects on the immune responses of peripheral blood mononuclear cells (PBMCs) and tumor growth inhibition could be improved by their combination. we demonstrate that the low-dose combination of CUR and RES reduced the survival of cancer cell lines but had no effect on the viability of PBMCs. although following CUR + RES treatment T lymphocytes showed an enhanced activated state, RES counteracted the increased IFN-γ expression induced by CUR in T cells and the polyphenol combination increased IL-10 production by T regulatory cells. on the other hand, the combined treatment enhanced NK cell activity through the up- and downregulation of activating and inhibitory receptors and increased CD68 expression levels on monocytes/macrophages. overall, our results indicate that the combination of CUR and RES at low doses differentially shapes immune cells while retaining antitumor activity, support the use of this polyphenol combinations in anticancer therapy and suggest its possible application as adjuvant for NK cell-based immunotherapies.

Focaccetti, C., Palumbo, C., Benvenuto, M., Carrano, R., Melaiu, O., Nardozi, D., et al. (2024). The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(1) [10.3390/ijms25010232].

The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival

Focaccetti C.;Palumbo C.;Benvenuto M.;Carrano R.;Melaiu O.;Nardozi D.;Cifaldi L.;Bei R.
2024-01-01

Abstract

the polyphenols curcumin (CUR) and resveratrol (RES) are widely described for their antitumoral effects. however, their low bioavailability is a drawback for their use in therapy. the aim of this study was to explore whether CUR and RES, used at a bioavailable concentration, could modulate immune responses while retaining antitumor activity and to determine whether CUR and RES effects on the immune responses of peripheral blood mononuclear cells (PBMCs) and tumor growth inhibition could be improved by their combination. we demonstrate that the low-dose combination of CUR and RES reduced the survival of cancer cell lines but had no effect on the viability of PBMCs. although following CUR + RES treatment T lymphocytes showed an enhanced activated state, RES counteracted the increased IFN-γ expression induced by CUR in T cells and the polyphenol combination increased IL-10 production by T regulatory cells. on the other hand, the combined treatment enhanced NK cell activity through the up- and downregulation of activating and inhibitory receptors and increased CD68 expression levels on monocytes/macrophages. overall, our results indicate that the combination of CUR and RES at low doses differentially shapes immune cells while retaining antitumor activity, support the use of this polyphenol combinations in anticancer therapy and suggest its possible application as adjuvant for NK cell-based immunotherapies.
2024
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/04
Settore MED/05
English
Con Impact Factor ISI
Curcumin
immune response
NK cells
PBMCs
polyphenols
Resveratrol
T cells
Focaccetti, C., Palumbo, C., Benvenuto, M., Carrano, R., Melaiu, O., Nardozi, D., et al. (2024). The Combination of Bioavailable Concentrations of Curcumin and Resveratrol Shapes Immune Responses While Retaining the Ability to Reduce Cancer Cell Survival. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25(1) [10.3390/ijms25010232].
Focaccetti, C; Palumbo, C; Benvenuto, M; Carrano, R; Melaiu, O; Nardozi, D; Angiolini, V; Lucarini, V; Kerpi, B; Masuelli, L; Cifaldi, L; Bei, R...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/348983
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