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EnglishThe entry of human immunodeficiency virus (HIV) into the central nervous system (CNS) causes both the establishment of a lifelong viral reservoir in the brain and symptoms of neurological dysfunction that have an AIDS dementia complex (ADC) clinical appearance. Neurological dysfunction in ADC patients still remains an unresolved problem. However, ADC pathogenesis may,be a multistep process that starts with HIV invasion of CNS by crossing the blood-brain barrier (BBB). It progresses by developing a chronic inflammatory status that can cause dysfunction in neurons and astrocytes that result in apoptotic death. Monocytes-macrophages (M/M) may play an important role by concealing the HIV transfer across the BBB. Furthermore, HIV-infected could produce and release neurotoxic factors. In this review the main mediators and cells involved in pathogenesis and development of ADC are highlighted. A better understanding of the mechanisms involved in this process may help in a successful therapeutic approach to the neuropathogenesis of HIV infection.
Aquaro, S., Ronga, L., Pollicita, M., Antinori, A., Ranazzi, A., & Perno, C.F. (2005). Human immunodeficiency virus infection and acquired immunodeficiency syndrome dementia complex: Role of cells of monocyte-macrophage lineage. In Journal of NeuroVirology (pp.58-66). PHILADELPHIA : TAYLOR & FRANCIS INC.
| Autori: | |
| Autori: | Aquaro, S; Ronga, L; Pollicita, M; Antinori, A; Ranazzi, A; Perno, CF |
| Titolo: | Human immunodeficiency virus infection and acquired immunodeficiency syndrome dementia complex: Role of cells of monocyte-macrophage lineage |
| Nome del convegno: | Symposium on HIV Infection and the Central Nervous System - Developed and Resource Limited Settings |
| Luogo del convegno: | Frascati, ITALY |
| Anno del convegno: | JUN 11-13, 2005 |
| Enti collegati al convegno: | Natl Inst Hlth, NINDS, Off AIDS Res |
| Rilevanza: | Rilevanza internazionale |
| Data di pubblicazione: | 2005 |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1080/13550280500513416 |
| Settore Scientifico Disciplinare: | Settore MED/07 - Microbiologia e Microbiologia Clinica |
| Lingua: | English |
| Tipologia: | Intervento a convegno |
| Citazione: | Aquaro, S., Ronga, L., Pollicita, M., Antinori, A., Ranazzi, A., & Perno, C.F. (2005). Human immunodeficiency virus infection and acquired immunodeficiency syndrome dementia complex: Role of cells of monocyte-macrophage lineage. In Journal of NeuroVirology (pp.58-66). PHILADELPHIA : TAYLOR & FRANCIS INC. |
| Appare nelle tipologie: | 02 - Intervento a convegno |
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