Diabetes Mellitus is a multifactorial disease with a critical impact worldwide. During prediabetes, the presence of various inflammatory cytokines and oxidative stress will lead to the pathogenesis of type 2 diabetes. Furthermore, insulin resistance and chronic hyperglycemia will lead to micro- and macrovascular complications (cardiovascular disease, heart failure, hypertension, chronic kidney disease, and atherosclerosis). The development through the years of pharmacological options allowed us to reduce the persistence of chronic hyperglycemia and reduce diabetic complications. This review aims to highlight the specific mechanisms with which the new treatments for type 2 diabetes reduce oxidative stress and insulin resistance and improve cardiovascular outcomes.

Andreadi, A., Muscoli, S., Tajmir, R., Meloni, M., Muscoli, C., Ilari, S., et al. (2023). Recent pharmacological options in type 2 diabetes and synergic mechanism in cardiovascular disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(2), 1-16 [10.3390/ijms24021646].

Recent pharmacological options in type 2 diabetes and synergic mechanism in cardiovascular disease

Andreadi A.;Muscoli S.;Meloni M.;Mollace V.;Della Morte D.;Bellia A.;Di Daniele N.;Tesauro M.;Lauro D.
2023-01-13

Abstract

Diabetes Mellitus is a multifactorial disease with a critical impact worldwide. During prediabetes, the presence of various inflammatory cytokines and oxidative stress will lead to the pathogenesis of type 2 diabetes. Furthermore, insulin resistance and chronic hyperglycemia will lead to micro- and macrovascular complications (cardiovascular disease, heart failure, hypertension, chronic kidney disease, and atherosclerosis). The development through the years of pharmacological options allowed us to reduce the persistence of chronic hyperglycemia and reduce diabetic complications. This review aims to highlight the specific mechanisms with which the new treatments for type 2 diabetes reduce oxidative stress and insulin resistance and improve cardiovascular outcomes.
13-gen-2023
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/09 - MEDICINA INTERNA
Settore MED/13 - ENDOCRINOLOGIA
English
Con Impact Factor ISI
cardiovascular complications
cardiovascular risk
diabetes mellitus
insulin resistance
oxidative stress
Andreadi, A., Muscoli, S., Tajmir, R., Meloni, M., Muscoli, C., Ilari, S., et al. (2023). Recent pharmacological options in type 2 diabetes and synergic mechanism in cardiovascular disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(2), 1-16 [10.3390/ijms24021646].
Andreadi, A; Muscoli, S; Tajmir, R; Meloni, M; Muscoli, C; Ilari, S; Mollace, V; Della Morte, D; Bellia, A; Di Daniele, N; Tesauro, M; Lauro, D...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/322122
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