Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of sulfur and selenium in biologically available forms, the restoration of iron-sulfur clusters, redox system maintenance and the mitochondrial import of 5S rRNA. Recently, the relevance of TST in metabolic diseases, such as diabetes, has been highlighted, opening the way for research on important aspects of sulfur metabolism in diabetes. This review underlines the structural and functional characteristics of TST, describing the physiological role and biomedical and biotechnological applications of this essential enzyme.

Buonvino, S., Arciero, I., Melino, S. (2022). Thiosulfate-cyanide sulfurtransferase a mitochondrial essential enzyme: from cell metabolism to the biotechnological applications. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(15) [10.3390/ijms23158452].

Thiosulfate-cyanide sulfurtransferase a mitochondrial essential enzyme: from cell metabolism to the biotechnological applications

Melino S.
Writing – Original Draft Preparation
2022-01-01

Abstract

Thiosulfate: cyanide sulfurtransferase (TST), also named rhodanese, is an enzyme widely distributed in both prokaryotes and eukaryotes, where it plays a relevant role in mitochondrial function. TST enzyme is involved in several biochemical processes such as: cyanide detoxification, the transport of sulfur and selenium in biologically available forms, the restoration of iron-sulfur clusters, redox system maintenance and the mitochondrial import of 5S rRNA. Recently, the relevance of TST in metabolic diseases, such as diabetes, has been highlighted, opening the way for research on important aspects of sulfur metabolism in diabetes. This review underlines the structural and functional characteristics of TST, describing the physiological role and biomedical and biotechnological applications of this essential enzyme.
2022
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
English
alpha-beta domain; biotechnology; cyanide; hydrogen sulfide; iron-sulfur clusters; redox system; rhodanese; Cyanides; Mitochondria; Sulfur; Thiosulfate Sulfurtransferase; Thiosulfates
Buonvino, S., Arciero, I., Melino, S. (2022). Thiosulfate-cyanide sulfurtransferase a mitochondrial essential enzyme: from cell metabolism to the biotechnological applications. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(15) [10.3390/ijms23158452].
Buonvino, S; Arciero, I; Melino, S
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/307536
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