Aims The aim of our study was to assess the effects of an early percutaneous coronary intervention on changes of in-hospital left ventricular ejection fraction (LVEF) and wall motion score index (WMSI) in patients with ST-segment elevation myocardial infarction. Methods The study population consisted of 324 consecutive patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention, divided into two groups, according to the first medical contact (FMC)-to-reperfusion time, respectively, 90 min or less (n = 173) and more than 90 min (n = 151). Moreover, we performed a sub-analysis in the group of patients who showed at discharge an improvement in the LVEF of at least 10%. Results In both groups at baseline, patients suffered from a moderately reduced LVEF (40.88 +/- 8.38% in <= 90 min group vs. 40.70 +/- 8.98% in >90 min group; P = 0.858). A WMSI of more than 1 was recorded uniformly: 1.71 +/- 0.37 in patients with FMC-to-reperfusion 90 min or less and 1.72 +/- 0.38 in patients more than 90 min (P = 0.810). At the time of discharge, a significant improvement in LVEF (43.82 +/- 8.38%, P = 0.001) and WMSI (1.60 +/- 0.41, P = 0.009) exclusively emerged in the 90 min or less group. Furthermore, we identified 105 patients who experienced an improvement in the LVEF of at least 10% compared with baseline values. In these patients FMC-to-reperfusion and total ischemic time resulted as significantly shorter, when compared with patients with LVEF improvement of less than 10%. Conclusion Our study confirms and reinforces the concept that reducing the duration of the time between FMC and reperfusion, as well as the total ischemic time influences a positive recovery of left ventricular global and regional function during in-hospital stay.

Cammalleri, V., Marsili, G., Stelitano, M., Tavernese, A., Mauceri, A., Macrini, M., et al. (2021). Every minute counts: in-hospital changes of left ventricular regional and global function in patients with ST-segment elevation myocardial infarction. JOURNAL OF CARDIOVASCULAR MEDICINE, 22(5), 363-370 [10.2459/JCM.0000000000001056].

Every minute counts: in-hospital changes of left ventricular regional and global function in patients with ST-segment elevation myocardial infarction

Cammalleri, V
;
Muscoli, S;Di Luozzo, M;Sergi, D;De Vico, P;Romeo, F
2021

Abstract

Aims The aim of our study was to assess the effects of an early percutaneous coronary intervention on changes of in-hospital left ventricular ejection fraction (LVEF) and wall motion score index (WMSI) in patients with ST-segment elevation myocardial infarction. Methods The study population consisted of 324 consecutive patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention, divided into two groups, according to the first medical contact (FMC)-to-reperfusion time, respectively, 90 min or less (n = 173) and more than 90 min (n = 151). Moreover, we performed a sub-analysis in the group of patients who showed at discharge an improvement in the LVEF of at least 10%. Results In both groups at baseline, patients suffered from a moderately reduced LVEF (40.88 +/- 8.38% in <= 90 min group vs. 40.70 +/- 8.98% in >90 min group; P = 0.858). A WMSI of more than 1 was recorded uniformly: 1.71 +/- 0.37 in patients with FMC-to-reperfusion 90 min or less and 1.72 +/- 0.38 in patients more than 90 min (P = 0.810). At the time of discharge, a significant improvement in LVEF (43.82 +/- 8.38%, P = 0.001) and WMSI (1.60 +/- 0.41, P = 0.009) exclusively emerged in the 90 min or less group. Furthermore, we identified 105 patients who experienced an improvement in the LVEF of at least 10% compared with baseline values. In these patients FMC-to-reperfusion and total ischemic time resulted as significantly shorter, when compared with patients with LVEF improvement of less than 10%. Conclusion Our study confirms and reinforces the concept that reducing the duration of the time between FMC and reperfusion, as well as the total ischemic time influences a positive recovery of left ventricular global and regional function during in-hospital stay.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/11
English
acute myocardial infarction
ST-segment elevation myocardial infarction
biomarkers
complications
percutaneous coronary intervention
Female
Hospitalization
Humans
Inpatients
Male
Middle Aged
Myocardial Ischemia
Patient Discharge
ST Elevation Myocardial Infarction
Treatment Outcome
Percutaneous Coronary Intervention
Recovery of Function
Stroke Volume
Time-to-Treatment
Cammalleri, V., Marsili, G., Stelitano, M., Tavernese, A., Mauceri, A., Macrini, M., et al. (2021). Every minute counts: in-hospital changes of left ventricular regional and global function in patients with ST-segment elevation myocardial infarction. JOURNAL OF CARDIOVASCULAR MEDICINE, 22(5), 363-370 [10.2459/JCM.0000000000001056].
Cammalleri, V; Marsili, G; Stelitano, M; Tavernese, A; Mauceri, A; Macrini, M; Stifano, G; Muscoli, S; Mollace, R; Di Luozzo, M; Sergi, D; De Vico, P; Romeo, F
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/304994
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact