Background and aims: Growing evidence suggests that the metabolic syndrome (MetS) has both genetic and environmental basis. To evaluate the opportunity of a further genetic analysis, we estimated prevalence rates and heritabilities for the MetS and its individual traits in the adult population of Linosa, a small and isolated Italian island in the southern-central part of Mediterranean Sea. Methods and results: We investigated 364 subjects (201 women, 163 men; aged 48±18 years, mean±SD). Pedigrees were constructed for 293 subjects from 51 families (123 parents; 170 offsprings). The MetS was defined according to NCEPATP III criteria and following prevalence rates were calculated: hyperglycaemia 20.3%; central obesity 34.9%; hypertension 43.4%; hypertriglyceridemia 29.9%; "low HDL" 56.6%; MetS 29.9%. Waist circumference was highly related to all the quantitative parameters included in the NCEP-ATP III MetS definition. The MetS showed an heritability of 27% (p=0.0012) and among its individual components, treated as continuous and discrete traits, heritability ranged from 10% for blood glucose to 54% for HDL-cholesterol. Insulin-resistance showed appreciable heritability when entered as discrete trait (32%, p<0.001) and even as HOMA-IR quantitative values (38%, p<0.001). Conclusion: These data showed high prevalence rates for the MetS and its related traits in an isolated and small Caucasian population. The appreciable heritability estimates for the MetS and some of its components in the Linosa population might support the observation of genetic factors underlying the pathogenesis of the MetS and encourage to perform an analysis to identify new susceptibility genes
Bellia, A., Giardina, E., Lauro, D., Tesauro, M., Di Fede, G., Cusumano, G., et al. (2009). The Linosa Study: epidemiological and heritability data of the metabolic syndrome in a Caucasian genetic isolate. NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 19(7), 455-461 [10.1016/j.numecd.2008.11.002].
The Linosa Study: epidemiological and heritability data of the metabolic syndrome in a Caucasian genetic isolate
BELLIA, ALFONSO;GIARDINA, EMILIANO;LAURO, DAVIDE;TESAURO, MANFREDI;FEDERICI, MASSIMO;NOVELLI, GIUSEPPE;LAURO, RENATO;SBRACCIA, PAOLO
2009-09-01
Abstract
Background and aims: Growing evidence suggests that the metabolic syndrome (MetS) has both genetic and environmental basis. To evaluate the opportunity of a further genetic analysis, we estimated prevalence rates and heritabilities for the MetS and its individual traits in the adult population of Linosa, a small and isolated Italian island in the southern-central part of Mediterranean Sea. Methods and results: We investigated 364 subjects (201 women, 163 men; aged 48±18 years, mean±SD). Pedigrees were constructed for 293 subjects from 51 families (123 parents; 170 offsprings). The MetS was defined according to NCEPATP III criteria and following prevalence rates were calculated: hyperglycaemia 20.3%; central obesity 34.9%; hypertension 43.4%; hypertriglyceridemia 29.9%; "low HDL" 56.6%; MetS 29.9%. Waist circumference was highly related to all the quantitative parameters included in the NCEP-ATP III MetS definition. The MetS showed an heritability of 27% (p=0.0012) and among its individual components, treated as continuous and discrete traits, heritability ranged from 10% for blood glucose to 54% for HDL-cholesterol. Insulin-resistance showed appreciable heritability when entered as discrete trait (32%, p<0.001) and even as HOMA-IR quantitative values (38%, p<0.001). Conclusion: These data showed high prevalence rates for the MetS and its related traits in an isolated and small Caucasian population. The appreciable heritability estimates for the MetS and some of its components in the Linosa population might support the observation of genetic factors underlying the pathogenesis of the MetS and encourage to perform an analysis to identify new susceptibility genesI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
