Metabolic syndrome (MS) is a complex disorder recognized clinically by the findings of abdominal obesity, elevated triglycerides, atherogenic dyslipidaemia, elevated blood pressure, high blood glucose and/or insulin resistance. It is associated with a pro-thrombotic and a pro-inflammatory state. A growing body of evidence suggests that individuals in the community with moderate airflow limitation may have co-existing systemic inflammation with this background. Therefore, we examined a population of 237 patients with metabolic disorder for the concomitant presence of functional pulmonary involvement, as assessed by FEV(1) and FVC impairment. Criteria for the identification of the MS included 3 or more of the following: waist circumference: (>102 cm in men, >88 cm in women), triglycerides levels (> or =150 mg/dl), high-density lipoprotein cholesterol levels (<40 mg/dl in men, <50 mg/dl in women), blood pressure (> or =135/> or =85 mmHg), and fasting glucose levels (>100 mg/dl). 119 subjects were diagnosed MS. Non-smokers patients suffering from MS presented lower spirometric values, with a trend to ventilatory restrictive more than obstructive pattern. Also in smokers patients with MS there was a trend to harmonic decrease in FEV(1) and FVC but not in FEV(1)/FVC ratio, although the changes did not reach statistical significance. Mainly abdominal circumference, and also insulin resistance were retained as independent predictors of both FEV(1) and FVC changes. However, HDL-C was the strongest predictor of FEV(1) and FVC changes, with an inverse association.
Rogliani, P., Curradi, G., Mura, M., Lauro, D., Federici, M., Galli, A., et al. (2010). Metabolic syndrome and risk of pulmonary involvement. RESPIRATORY MEDICINE, 104(1), 47-51.
|Tipologia:||Articolo su rivista|
|Citazione:||Rogliani, P., Curradi, G., Mura, M., Lauro, D., Federici, M., Galli, A., et al. (2010). Metabolic syndrome and risk of pulmonary involvement. RESPIRATORY MEDICINE, 104(1), 47-51.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/10 - Malattie dell'Apparato Respiratorio|
Settore MED/50 - Scienze Tecniche Mediche Applicate
Settore MED/09 - Medicina Interna
Settore M-EDF/01 - Metodi e Didattiche delle Attivita' Motorie
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.rmed.2009.08.009|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||gen-2010|
|Titolo:||Metabolic syndrome and risk of pulmonary involvement|
|Autori:||Rogliani, P; Curradi, G; Mura, M; Lauro, D; Federici, M; Galli, A; Saltini, C; Cazzola, M|
|Appare nelle tipologie:||01 - Articolo su rivista|