Ischemic stroke (IS) is still among the leading causes of death and disability worldwide. The pathogenic mechanisms beyond its development are several and are complex and this is the main reason why a functional therapy is still missed. The beneficial effects of natural compounds against cardiovascular diseases and IS have been investigated for a long time. In this article, we reviewed the association between the most studied polyphenols and stroke protection in terms of prevention, effect on acute phase, and rehabilitation. We described experimental and epidemiological studies reporting the role of flavonols, phenolic acid, and stilbens on ischemic mechanisms leading to stroke. We analyzed the principal animal models used to evaluate the impact of these micronutrients to cerebral blood flow and to molecular pathways involved in oxidative stress and inflammation modulation, such as sirtuins. We reported the most significant clinical trials demonstrated as the persistent use of polyphenols is clinically relevant in terms of the reduction of vascular risk factors for IS, such as Atrial Fibrillation. Interestingly, different kinds of polyphenols provide brain protection by activating different pathways and mechanisms, like inducing antithrombotic effect, such as Honokiol. For this reason, we discussed an appropriate integrative use of them as a possible therapeutic alternative against stroke.

Pacifici, F., Rovella, V., Pastore, D., Bellia, A., Abete, P., Donadel, G., et al. (2021). Polyphenols and ischemic stroke: Insight into one of the best strategies for prevention and treatment. NUTRIENTS, 13(6), 1967 [10.3390/nu13061967].

Polyphenols and ischemic stroke: Insight into one of the best strategies for prevention and treatment

Pacifici F.;Rovella V.;Pastore D.;Bellia A.;Donadel G.;Santini S.;Di Daniele N.;Lauro D.;Della-Morte D.
2021-01-01

Abstract

Ischemic stroke (IS) is still among the leading causes of death and disability worldwide. The pathogenic mechanisms beyond its development are several and are complex and this is the main reason why a functional therapy is still missed. The beneficial effects of natural compounds against cardiovascular diseases and IS have been investigated for a long time. In this article, we reviewed the association between the most studied polyphenols and stroke protection in terms of prevention, effect on acute phase, and rehabilitation. We described experimental and epidemiological studies reporting the role of flavonols, phenolic acid, and stilbens on ischemic mechanisms leading to stroke. We analyzed the principal animal models used to evaluate the impact of these micronutrients to cerebral blood flow and to molecular pathways involved in oxidative stress and inflammation modulation, such as sirtuins. We reported the most significant clinical trials demonstrated as the persistent use of polyphenols is clinically relevant in terms of the reduction of vascular risk factors for IS, such as Atrial Fibrillation. Interestingly, different kinds of polyphenols provide brain protection by activating different pathways and mechanisms, like inducing antithrombotic effect, such as Honokiol. For this reason, we discussed an appropriate integrative use of them as a possible therapeutic alternative against stroke.
2021
Pubblicato
Rilevanza internazionale
Recensione
Esperti anonimi
Settore MED/09 - MEDICINA INTERNA
Settore MED/46 - SCIENZE TECNICHE DI MEDICINA E DI LABORATORIO
Settore MED/13 - ENDOCRINOLOGIA
Settore MED/49 - SCIENZE TECNICHE DIETETICHE APPLICATE
English
cardiovascular disease
nutraceutical
phytochemicals
sirtuins
Animals
Brain Ischemia
Disease Models, Animal
Humans
Oxidative Stress
Polyphenols
Stroke
Stroke Rehabilitation
Pacifici, F., Rovella, V., Pastore, D., Bellia, A., Abete, P., Donadel, G., et al. (2021). Polyphenols and ischemic stroke: Insight into one of the best strategies for prevention and treatment. NUTRIENTS, 13(6), 1967 [10.3390/nu13061967].
Pacifici, F; Rovella, V; Pastore, D; Bellia, A; Abete, P; Donadel, G; Santini, S; Beck, H; Ricordi, C; Di Daniele, N; Lauro, D; Della-Morte, D
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/295009
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