S-nitrosylation of proteins is a nitric oxide (NO)-based post-translational modification of cysteine residues. By removing the NO moiety from S-nitrosothiol adducts, denitrosylases restore sulfhydryl protein pool and act as downstream tuners of S-nitrosylation signaling. Alterations in the S-nitrosylation/denitrosylation dynamics are implicated in many pathological states, including cancer ontogenesis and progression, skeletal muscle myogenesis and function. Here, we aim to provide and link different lines of evidence, and elaborate on the possible role of S-nitrosylation/denitrosylation signaling in rhabdomyosarcoma, one of the most common pediatric mesenchymal malignancy.

Montagna, C., Filomeni, G. (2022). Looking at denitrosylation to understand the myogenesis gone awry theory of rhabdomyosarcoma. NITRIC OXIDE, 122-123, 1-5 [10.1016/j.niox.2022.02.001].

Looking at denitrosylation to understand the myogenesis gone awry theory of rhabdomyosarcoma

Montagna, Costanza
Writing – Original Draft Preparation
;
Filomeni, Giuseppe
Supervision
2022-02-16

Abstract

S-nitrosylation of proteins is a nitric oxide (NO)-based post-translational modification of cysteine residues. By removing the NO moiety from S-nitrosothiol adducts, denitrosylases restore sulfhydryl protein pool and act as downstream tuners of S-nitrosylation signaling. Alterations in the S-nitrosylation/denitrosylation dynamics are implicated in many pathological states, including cancer ontogenesis and progression, skeletal muscle myogenesis and function. Here, we aim to provide and link different lines of evidence, and elaborate on the possible role of S-nitrosylation/denitrosylation signaling in rhabdomyosarcoma, one of the most common pediatric mesenchymal malignancy.
16-feb-2022
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/10 - BIOCHIMICA
English
https://www.sciencedirect.com/science/article/abs/pii/S1089860322000246?via=ihub
Montagna, C., Filomeni, G. (2022). Looking at denitrosylation to understand the myogenesis gone awry theory of rhabdomyosarcoma. NITRIC OXIDE, 122-123, 1-5 [10.1016/j.niox.2022.02.001].
Montagna, C; Filomeni, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/292055
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