Interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, activated natural killer T cells, and T follicular cells, has been reported to play a crucial role in the tissue-damaging T cell response in various organs, such as gut, skin, pancreas, and joints. This pathogenic effect is strictly linked to the ability of IL-21 to enhance the functional activities of multiple immune and non-immune cells. Consistently, studies from various laboratories have shown that blockade of IL-21 limits the progression of T cell-mediated inflammatory diseases in mice. Here we review the present knowledge on the expression and role of IL-21 in T cell-mediated pathologies.

Monteleone, G., Sarra, M., Pallone, F. (2009). Interleukin-21 in T cell-mediated diseases. DISCOVERY MEDICINE, 8(42), 113-117.

Interleukin-21 in T cell-mediated diseases

MONTELEONE, GIOVANNI;PALLONE, FRANCESCO
2009-10-01

Abstract

Interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, activated natural killer T cells, and T follicular cells, has been reported to play a crucial role in the tissue-damaging T cell response in various organs, such as gut, skin, pancreas, and joints. This pathogenic effect is strictly linked to the ability of IL-21 to enhance the functional activities of multiple immune and non-immune cells. Consistently, studies from various laboratories have shown that blockade of IL-21 limits the progression of T cell-mediated inflammatory diseases in mice. Here we review the present knowledge on the expression and role of IL-21 in T cell-mediated pathologies.
ott-2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
Animals; Humans; Interleukins; Autoimmunity; Mice; T-Lymphocytes; Inflammation
PMID: 19833056
Monteleone, G., Sarra, M., Pallone, F. (2009). Interleukin-21 in T cell-mediated diseases. DISCOVERY MEDICINE, 8(42), 113-117.
Monteleone, G; Sarra, M; Pallone, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/28864
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