Naïve T cells can commit to effector [T helper 1 (Th1), Th2 and Th17] or regulatory lineages. Skewing of responses toward inflammatory Th1, Th2 or Th17 pathways and away from regulatory T-cell pathways might be responsible for the initiation and progress of immune-mediated diseases. Based on recent data, we propose that interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, induces the development of Th17 cells, blocks the differentiation of transforming growth factor-β1-induced regulatory T cells and renders CD4+ T cells resistant to the suppressive effects of regulatory T cells, thereby playing a major role in pathogenic T-cell responses. © 2008 Elsevier Ltd. All rights reserved.

Monteleone, G., Pallone, F., Macdonald, T.t. (2008). Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. TRENDS IN IMMUNOLOGY, 29(6), 290-294 [10.1016/j.it.2008.02.008].

Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses

MONTELEONE, GIOVANNI;PALLONE, FRANCESCO;
2008-01-01

Abstract

Naïve T cells can commit to effector [T helper 1 (Th1), Th2 and Th17] or regulatory lineages. Skewing of responses toward inflammatory Th1, Th2 or Th17 pathways and away from regulatory T-cell pathways might be responsible for the initiation and progress of immune-mediated diseases. Based on recent data, we propose that interleukin-21 (IL-21), a cytokine produced by activated CD4+ T cells, induces the development of Th17 cells, blocks the differentiation of transforming growth factor-β1-induced regulatory T cells and renders CD4+ T cells resistant to the suppressive effects of regulatory T cells, thereby playing a major role in pathogenic T-cell responses. © 2008 Elsevier Ltd. All rights reserved.
2008
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/12 - GASTROENTEROLOGIA
English
interleukin 21; transforming growth factor beta1; CD4+ T lymphocyte; effector cell; human; nonhuman; regulatory T lymphocyte; review; T lymphocyte activation; Th1 cell; Th2 cell; Animals; Antibody Formation; B-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Proliferation; Humans; Immune System Diseases; Inflammation; Interleukins; Lymphocyte Activation; Th1 Cells; Th2 Cells; Transforming Growth Factor beta1
Monteleone, G., Pallone, F., Macdonald, T.t. (2008). Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses. TRENDS IN IMMUNOLOGY, 29(6), 290-294 [10.1016/j.it.2008.02.008].
Monteleone, G; Pallone, F; Macdonald, Tt
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/28769
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