Interleukin-21 (IL-21) is a newly described cytokine, produced by activated CD4+ T cells. Since the discovery in 2000, IL-21 has been the object of intensive research because of its homology to IL-2, IL-4 and IL-15, and its ability to modulate both innate and adaptive immune responses. IL-21 mediates its functions through a heterodimeric receptor, composed of a specific subunit, termed IL-21 receptor (IL-21R) and the common Î³-chain, that is shared with IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15 receptors. IL-21R is originally described on T, B and NK cells, which is in accordance with the cell types that mostly respond to IL-21. Indeed, IL-21 augments the proliferation of CD4+ and CD8+ T lymphocytes and regulates the profile of cytokines secreted by these cells, drives the differentiation of B cells into memory cells and terminally differentiated plasma cells, and moreover, enhances the activity of natural killer cells. More recently, IL-21R has also been documented on non-immune cells, raising the possibility that IL-21 is an important mediator in the cross-talk between immune and non-immune cells. As discussed in this review, the potential role of IL-21 in immune-mediated and allergic diseases would seem to suggest that either disrupting or enhancing IL-21 signaling may be useful in specific clinical settings. Â© 2007 Bentham Science Publishers Ltd.
Fina D., F.M. (2007). Role of interleukin-21 in inflammation and allergy. INFLAMMATION & ALLERGY - DRUG TARGETS, 6(1), 63-68.
|Tipologia:||Articolo su rivista|
|Citazione:||Fina D., F.M. (2007). Role of interleukin-21 in inflammation and allergy. INFLAMMATION & ALLERGY - DRUG TARGETS, 6(1), 63-68.|
|Settore Scientifico Disciplinare:||Settore MED/12 - Gastroenterologia|
|Revisione (peer review):||Sì, ma tipo non specificato|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2174/187152807780077246|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2007|
|Titolo:||Role of interleukin-21 in inflammation and allergy|
|Autori:||Fina D., Fantini M.C., Pallone F., Monteleone G.|
|Appare nelle tipologie:||01 - Articolo su rivista|