the coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 currently affected more than 108 million people worldwide with a fatality rate of 2.2%. herein, we report the first case of liver transplantation (LT) performed with a liver procured from a SARS-CoV-2 positive donor. the recipient was a 35-year-old SARS-CoV-2 positive female patient affected by severe end-stage HBV-HDV-related liver disease (model of end-stage liver disease = 32) who had neutralizing SARS-CoV-2 antibodies (titers 1:320) at time of LT. the LT was successful, and the graft is functioning two months after surgery. the recipient cleared the SARS-CoV-2 infection 1 month after LT. the current case shows that the prompt use of SARS-CoV-2 infected liver donors offers an invaluable life-saving opportunity for SARS-CoV-2 positive wait-listed patients who developed neutralizing SARS-CoV-2 antibodies.

Manzia, T.m., Gazia, C., Lenci, I., Angelico, R., Toti, L., Monaco, A., et al. (2021). Liver transplantation performed in a SARS-CoV-2 positive hospitalized recipient using a SARS-CoV-2 infected donor. AMERICAN JOURNAL OF TRANSPLANTATION, 21(7), 2600-2604 [10.1111/ajt.16548].

Liver transplantation performed in a SARS-CoV-2 positive hospitalized recipient using a SARS-CoV-2 infected donor

Manzia, Tommaso Maria;Lenci, Ilaria;Angelico, Roberta;Toti, Luca;Monaco, Andrea;Anselmo, Alessandro;Baiocchi, Leonardo;Tisone, Giuseppe
2021-01-01

Abstract

the coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 currently affected more than 108 million people worldwide with a fatality rate of 2.2%. herein, we report the first case of liver transplantation (LT) performed with a liver procured from a SARS-CoV-2 positive donor. the recipient was a 35-year-old SARS-CoV-2 positive female patient affected by severe end-stage HBV-HDV-related liver disease (model of end-stage liver disease = 32) who had neutralizing SARS-CoV-2 antibodies (titers 1:320) at time of LT. the LT was successful, and the graft is functioning two months after surgery. the recipient cleared the SARS-CoV-2 infection 1 month after LT. the current case shows that the prompt use of SARS-CoV-2 infected liver donors offers an invaluable life-saving opportunity for SARS-CoV-2 positive wait-listed patients who developed neutralizing SARS-CoV-2 antibodies.
2021
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/18 - CHIRURGIA GENERALE
Settore MED/12 - GASTROENTEROLOGIA
Settore MEDS-06/A - Chirurgia generale
English
clinical research/practice; donors and donation: extended criteria; infection and infectious agents - viral,
infectious disease; liver transplantation/hepatology; organ procurement and allocation; Adult; Female;
Humans; SARS-CoV-2; Tissue Donors; Waiting Lists; COVID-19; Liver Transplantation
Manzia, T.m., Gazia, C., Lenci, I., Angelico, R., Toti, L., Monaco, A., et al. (2021). Liver transplantation performed in a SARS-CoV-2 positive hospitalized recipient using a SARS-CoV-2 infected donor. AMERICAN JOURNAL OF TRANSPLANTATION, 21(7), 2600-2604 [10.1111/ajt.16548].
Manzia, Tm; Gazia, C; Lenci, I; Angelico, R; Toti, L; Monaco, A; Anselmo, A; Baiocchi, L; Grossi, P; Tisone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/277505
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