Undecanoic acid (UDA) is a fatty acid with significant antimycotic activity. In this work we have synthesized 10-undecanhydroxamic acid, a hydroxamate derivative of the UDA, and tested its antimicrobial activity on different microorganisms. Our results demonstrate that this compound has higher efficacy than UDA against a variety of fungi and bacteria. Analysis of the intracellular concentration of protein involved in iron transport in Salmonella enterica serovar Typhimurium suggests that its antimicrobial effect actually relies on the ability to chelate iron ions, providing an efficient mechanism to interfere with microbial growth.

Ammendola, S., Lembo, A., Battistoni, A., Tagliatesta, P., Ghisalberti, C., Desideri, A. (2009). 10-undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong antimicrobial activity through a mechanism that limits iron availability. FEMS MICROBIOLOGY LETTERS, 294(1), 61-67 [10.1111/j.1574-6968.2009.01537.x].

10-undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong antimicrobial activity through a mechanism that limits iron availability

Ammendola S;Lembo A;Battistoni A;Tagliatesta P;Desideri A
2009-01-01

Abstract

Undecanoic acid (UDA) is a fatty acid with significant antimycotic activity. In this work we have synthesized 10-undecanhydroxamic acid, a hydroxamate derivative of the UDA, and tested its antimicrobial activity on different microorganisms. Our results demonstrate that this compound has higher efficacy than UDA against a variety of fungi and bacteria. Analysis of the intracellular concentration of protein involved in iron transport in Salmonella enterica serovar Typhimurium suggests that its antimicrobial effect actually relies on the ability to chelate iron ions, providing an efficient mechanism to interfere with microbial growth.
2009
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/10 - BIOCHIMICA
English
Con Impact Factor ISI
Antimicrobial; Fur; Hydroxamate; Iron homeostasis; Undecanoic acid
Ammendola, S., Lembo, A., Battistoni, A., Tagliatesta, P., Ghisalberti, C., Desideri, A. (2009). 10-undecanhydroxamic acid, a hydroxamate derivative of the undecanoic acid, has strong antimicrobial activity through a mechanism that limits iron availability. FEMS MICROBIOLOGY LETTERS, 294(1), 61-67 [10.1111/j.1574-6968.2009.01537.x].
Ammendola, S; Lembo, A; Battistoni, A; Tagliatesta, P; Ghisalberti, C; Desideri, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/26128
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