Active Crohn's disease has a substantial impact on Quality of Life (QoL). Medical management could be associated to side effects, hospitalization, long treatment period and requires patient's compliance, impacting QoL. Ileocecal resection (ICR) is often required, open or laparoscopic. Aim of the study was to assess Health-Related (HR) QoL changes following ICR, and to identify factors impacting on QoL in the short and mid-term. From a single institution, we created a prospective database of patients undergoing ICR from 01/2009 to 12/2015. HRQoL was analysed with Cleveland Global Quality of Life (CGQL) score, Overall Quality of Happiness (OQH), and asking patients if they would have surgery again. QoL scores were recorded at 30 days, 6, 12 and 36 months postoperatively and compared according to follow-up timing, technique, medical treatment and demographics. Statistical analysis included 187 patients. Mean follow-up was 3.8 +/- 2.9 years. Both at 30 days and 6 months postoperatively, CGQL, its items and OQH increased significantly (p < 0.001). Increased values were also recorded at 1 and 3 years; 88% of patients would undergo surgery again. Laparoscopy was associated with improved CGQL scores, while preoperative steroids with worsen data. Young female patients, with penetrating pattern, experienced greater HRQoL improvements. Surgery is associated with improvements of HRQoL and patients' happiness in the short and mid-term. Laparoscopy, steroid-free and young patients showed the best results. ICR should be considered a reasonable alternative to non-operative strategies in selected cases.

D'Ugo, S., Romano, F., Sibio, S., Bagaglini, G., Sensi, B., Biancone, L., et al. (2020). Impact of surgery on quality of life in Crohn's disease: short- and mid-term follow-up. UPDATES IN SURGERY, 72(3), 773-780 [10.1007/s13304-020-00738-1].

Impact of surgery on quality of life in Crohn's disease: short- and mid-term follow-up

D'Ugo, Stefano;Biancone, Livia;Sica, Giuseppe
2020-09

Abstract

Active Crohn's disease has a substantial impact on Quality of Life (QoL). Medical management could be associated to side effects, hospitalization, long treatment period and requires patient's compliance, impacting QoL. Ileocecal resection (ICR) is often required, open or laparoscopic. Aim of the study was to assess Health-Related (HR) QoL changes following ICR, and to identify factors impacting on QoL in the short and mid-term. From a single institution, we created a prospective database of patients undergoing ICR from 01/2009 to 12/2015. HRQoL was analysed with Cleveland Global Quality of Life (CGQL) score, Overall Quality of Happiness (OQH), and asking patients if they would have surgery again. QoL scores were recorded at 30 days, 6, 12 and 36 months postoperatively and compared according to follow-up timing, technique, medical treatment and demographics. Statistical analysis included 187 patients. Mean follow-up was 3.8 +/- 2.9 years. Both at 30 days and 6 months postoperatively, CGQL, its items and OQH increased significantly (p < 0.001). Increased values were also recorded at 1 and 3 years; 88% of patients would undergo surgery again. Laparoscopy was associated with improved CGQL scores, while preoperative steroids with worsen data. Young female patients, with penetrating pattern, experienced greater HRQoL improvements. Surgery is associated with improvements of HRQoL and patients' happiness in the short and mid-term. Laparoscopy, steroid-free and young patients showed the best results. ICR should be considered a reasonable alternative to non-operative strategies in selected cases.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/18
English
Con Impact Factor ISI
Crohn’s disease
Laparoscopic surgery
Laparoscopy
Quality of life
Surgery
Adult
Crohn Disease
Female
Follow-Up Studies
Happiness
Humans
Male
Middle Aged
Time Factors
Treatment Outcome
Young Adult
Quality of Life
D'Ugo, S., Romano, F., Sibio, S., Bagaglini, G., Sensi, B., Biancone, L., et al. (2020). Impact of surgery on quality of life in Crohn's disease: short- and mid-term follow-up. UPDATES IN SURGERY, 72(3), 773-780 [10.1007/s13304-020-00738-1].
D'Ugo, S; Romano, F; Sibio, S; Bagaglini, G; Sensi, B; Biancone, L; Monteleone, G; Sica, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/260864
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