Celiac disease (CD) is a chronic enteropathy that develops in genetically susceptible individuals after the ingestion of gluten. There has been a substantial increase in CD prevalence in the last 50 years, and it is now estimated that this disease affects approximately 1% of the population in the Western world. In the large majority of cases, CD is a benign disease, characterized by the complete resolution of symptoms and a normal life expectancy after the onset of a gluten-free diet (GFD). However, failure to adhere to a strict GFD bears the risk of adverse events and increases mortality. A considerable number of studies have considered the possible association between CD and neoplasms. In particular, an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported. In this review, we summarize and discuss the current evidence on the possible association between CD and cancer.

Marafini, I., Monteleone, G., Stolfi, C. (2020). Association between celiac disease and cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(11), 1-14 [10.3390/ijms21114155].

Association between celiac disease and cancer

Marafini, Irene;Monteleone, Giovanni;Stolfi, Carmine
2020-01-01

Abstract

Celiac disease (CD) is a chronic enteropathy that develops in genetically susceptible individuals after the ingestion of gluten. There has been a substantial increase in CD prevalence in the last 50 years, and it is now estimated that this disease affects approximately 1% of the population in the Western world. In the large majority of cases, CD is a benign disease, characterized by the complete resolution of symptoms and a normal life expectancy after the onset of a gluten-free diet (GFD). However, failure to adhere to a strict GFD bears the risk of adverse events and increases mortality. A considerable number of studies have considered the possible association between CD and neoplasms. In particular, an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported. In this review, we summarize and discuss the current evidence on the possible association between CD and cancer.
2020
Pubblicato
Rilevanza internazionale
Review
Esperti anonimi
Settore MED/12 - GASTROENTEROLOGIA
Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
Settore MEDS-10/A - Gastroenterologia
Settore BIOS-09/A - Biochimica clinica e biologia molecolare clinica
English
HLA-DQ2
HLA-DQ8
T-cell lymphoma
colorectal cancer
gluten
gluten-free diet
refractory celiac disease
small bowel adenocarcinoma
Marafini, I., Monteleone, G., Stolfi, C. (2020). Association between celiac disease and cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(11), 1-14 [10.3390/ijms21114155].
Marafini, I; Monteleone, G; Stolfi, C
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/253626
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