Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
Marino, M., Pontrelli, G., Vairo, G., & Wriggers, P. (2017). Coupling Microscale Transport and Tissue Mechanics: Modeling Strategies for Arterial Multiphysics. In Modeling of Microscale Transport in Biological Processes (pp. 77-112). Elsevier Inc. [10.1016/B978-0-12-804595-4.00004-3].
Coupling Microscale Transport and Tissue Mechanics: Modeling Strategies for Arterial Multiphysics
Marino M.;Pontrelli G.;Vairo G.;
2017
Abstract
Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
