Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.

Marino, M., Pontrelli, G., Vairo, G., & Wriggers, P. (2017). Coupling Microscale Transport and Tissue Mechanics: Modeling Strategies for Arterial Multiphysics. In Modeling of Microscale Transport in Biological Processes (pp. 77-112). Elsevier Inc. [10.1016/B978-0-12-804595-4.00004-3].

Coupling Microscale Transport and Tissue Mechanics: Modeling Strategies for Arterial Multiphysics

Marino M.;Pontrelli G.;Vairo G.;
2017

Abstract

Arterial physiopathological behavior involves multiphysics mechanisms, as the result of the complex interplay between microscale transport phenomena and mechanical equilibrium. This chapter draws a modeling strategy for coupling macroscopic mechanics and molecular diffusive/reactive mechanisms via biochemically-motivated tissue remodeling laws.Results have been obtained by addressing the effects of extracellular matrix remodeling driven by matrix metalloproteinases, transforming growth factor-beta and interleukines on the compliance of an axisymmetric arterial segment. Remarkably, obtained results show that the present approach is able to capture arterial dilation as a consequence of alterations in the cellular activity, as well as to incorporate the protective role of pharmacological treatments.
Settore ICAR/08
eng
Rilevanza internazionale
Capitolo o saggio
Arterial multiphysics; Arterial tissues; Biomechanics; Microscale transport process; Multiscale constitutive model; Tissue remodeling; Vascular pathologies
https://www.sciencedirect.com/science/article/pii/B9780128045954000043?via=ihub
Marino, M., Pontrelli, G., Vairo, G., & Wriggers, P. (2017). Coupling Microscale Transport and Tissue Mechanics: Modeling Strategies for Arterial Multiphysics. In Modeling of Microscale Transport in Biological Processes (pp. 77-112). Elsevier Inc. [10.1016/B978-0-12-804595-4.00004-3].
Marino, M; Pontrelli, G; Vairo, G; Wriggers, P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/241692
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