BKPyV replication is a risk factor for the development of polyomavirus-associated nephropathy in kidney transplant recipients. Here, the case of a 42 years old Caucasian patient is described who developed a kidney allograft failure because of uncontrolled BKPyV replication 7 months after transplant despite a strong reduction of the immunosuppressive therapy. The genetic analysis of the noncoding control region did not show rearrangement but two point mutations at nucleotide positions 18 and 31 within P block. The mutation at position 31 involved the nuclear factor-1 site. Sequencing of the VP1 region revealed a subtype I/subgroup b-1.

Anselmo, A., Prezioso, C., Sacca, F.a., Di Lella, F.m., Palmieri, G., Tisone, G., et al. (2019). Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy. JOURNAL OF MEDICAL VIROLOGY, 91(9), 1698-1701 [10.1002/jmv.25458].

Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy

Anselmo A.;Palmieri G.;Tisone G.;
2019-01-01

Abstract

BKPyV replication is a risk factor for the development of polyomavirus-associated nephropathy in kidney transplant recipients. Here, the case of a 42 years old Caucasian patient is described who developed a kidney allograft failure because of uncontrolled BKPyV replication 7 months after transplant despite a strong reduction of the immunosuppressive therapy. The genetic analysis of the noncoding control region did not show rearrangement but two point mutations at nucleotide positions 18 and 31 within P block. The mutation at position 31 involved the nuclear factor-1 site. Sequencing of the VP1 region revealed a subtype I/subgroup b-1.
2019
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/18 - CHIRURGIA GENERALE
English
BKPyV; PVAN; VP1; immunosuppressive therapy; kidney transplant; noncoding control region (NCCR)
Anselmo, A., Prezioso, C., Sacca, F.a., Di Lella, F.m., Palmieri, G., Tisone, G., et al. (2019). Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy. JOURNAL OF MEDICAL VIROLOGY, 91(9), 1698-1701 [10.1002/jmv.25458].
Anselmo, A; Prezioso, C; Sacca, Fa; Di Lella, Fm; Palmieri, G; Tisone, G; Pietropaolo, V; Ciotti, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/241499
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