BKPyV replication is a risk factor for the development of polyomavirus-associated nephropathy in kidney transplant recipients. Here, the case of a 42 years old Caucasian patient is described who developed a kidney allograft failure because of uncontrolled BKPyV replication 7 months after transplant despite a strong reduction of the immunosuppressive therapy. The genetic analysis of the noncoding control region did not show rearrangement but two point mutations at nucleotide positions 18 and 31 within P block. The mutation at position 31 involved the nuclear factor-1 site. Sequencing of the VP1 region revealed a subtype I/subgroup b-1.
Anselmo, A., Prezioso, C., Sacca, F.a., Di Lella, F.m., Palmieri, G., Tisone, G., et al. (2019). Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy. JOURNAL OF MEDICAL VIROLOGY, 91(9), 1698-1701 [10.1002/jmv.25458].
Kidney graft failure induced by BKPyV replication despite a strong reduction of the immunosuppressive therapy
Anselmo A.;Palmieri G.;Tisone G.;
2019-01-01
Abstract
BKPyV replication is a risk factor for the development of polyomavirus-associated nephropathy in kidney transplant recipients. Here, the case of a 42 years old Caucasian patient is described who developed a kidney allograft failure because of uncontrolled BKPyV replication 7 months after transplant despite a strong reduction of the immunosuppressive therapy. The genetic analysis of the noncoding control region did not show rearrangement but two point mutations at nucleotide positions 18 and 31 within P block. The mutation at position 31 involved the nuclear factor-1 site. Sequencing of the VP1 region revealed a subtype I/subgroup b-1.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
