CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishA model describing the role of transversal and longitudinal diffusion of cGMP and Ca2+ in signaling in the rod outer segment of vertebrates is developed. Utilizing a novel notion of surface-volume reaction and the mathematical theories of homogenization and concentrated capacity, the diffusion of cGMP CGMP and Ca2+ in the interdiscal spaces is shown to be reducible to a one-parameter family of diffusion processes taking place on a single rod cross section; whereas the diffusion in the outer shell is shown to be reducible to a diffusion on a cylindrical surface. Moreover, the exterior flux of the former serves as a source term for the latter, alleviating the assumption of a well-stirred cytosol. A previous model of visual transduction that assumes a well-stirred rod outer segment cytosol (and thus contains no spatial information) can be recovered from this model by imposing a "bulk" assumption. The model shows that upon activation of a single rhodopsin, cGMP changes are local, and exhibit both a longitudinal and a transversal component. Consequently, membrane current is also highly localized. The spatial spread of the single photon response along the longitudinal axis of the outer segment is predicted to be 3-5 μm, consistent with experimental data. This approach represents a tool to analyze pointwise signaling dynamics without requiring averaging over the entire cell by global Michaelis-Menten kinetics.
Andreucci, D., Bisegna, P., Caruso, G., Hamm, H., & DiBenedetto, E. (2003). Mathematical model of the spatio-temporal dynamics of second messengers in visual transduction. BIOPHYSICAL JOURNAL, 85(3), 1358-1376.
| Tipologia: | Articolo su rivista |
| Citazione: | Andreucci, D., Bisegna, P., Caruso, G., Hamm, H., & DiBenedetto, E. (2003). Mathematical model of the spatio-temporal dynamics of second messengers in visual transduction. BIOPHYSICAL JOURNAL, 85(3), 1358-1376. |
| IF: | Con Impact Factor ISI |
| Lingua: | English |
| Settore Scientifico Disciplinare: | Settore ICAR/08 - Scienza delle Costruzioni Settore ING-IND/34 - Bioingegneria Industriale Settore BIO/10 |
| Revisione (peer review): | Sì, ma tipo non specificato |
| Tipo: | Articolo |
| Rilevanza: | Rilevanza internazionale |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0006-3495(03)74570-6 |
| Stato di pubblicazione: | Pubblicato |
| Data di pubblicazione: | 2003 |
| Titolo: | Mathematical model of the spatio-temporal dynamics of second messengers in visual transduction |
| Autori: | |
| Autori: | Andreucci, D; Bisegna, P; Caruso, G; Hamm, H.E; DiBenedetto, E |
| Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Fototransduction_BJ.pdf | Articolo | N/A | Open Access Visualizza/Apri |
Copyright © 2021