The presence of SENV and TTV infections among 50 patients who had undergone liver transplantation was evaluated. UTR amplification showed that 46 (92%) sera were positive. ORF-1 amplification showed that 25 (50%) patients were positive for either SENV (51.3%), TTV (10.8%), or both (37.8%) all confirmed by sequencing and phylogenetic analysis. SENV-D and SENV-H were the most prevalent viruses. The phylogenetic analysis of isolates showed that whereas SENV-D and SENV-G viruses showed sequence stability and strain persistence, SENV-H had cleared or mutated. Biological differences seem to exist among different genotypes in terms of viral replication and their persistence.
Genovese, D., Dettori, S., Argentini, C., Kondili, L., La Sorsa, V., Tisone, G., et al. (2004). Molecular characterisation of SENV and TTV infections in hepatopathic liver-transplant patients. Brief Report. ARCHIVES OF VIROLOGY, 1423-1433 [10.1007/s00705-004-0320-0].
Molecular characterisation of SENV and TTV infections in hepatopathic liver-transplant patients. Brief Report.
TISONE, GIUSEPPE;ANGELICO, MARIO;
2004-01-01
Abstract
The presence of SENV and TTV infections among 50 patients who had undergone liver transplantation was evaluated. UTR amplification showed that 46 (92%) sera were positive. ORF-1 amplification showed that 25 (50%) patients were positive for either SENV (51.3%), TTV (10.8%), or both (37.8%) all confirmed by sequencing and phylogenetic analysis. SENV-D and SENV-H were the most prevalent viruses. The phylogenetic analysis of isolates showed that whereas SENV-D and SENV-G viruses showed sequence stability and strain persistence, SENV-H had cleared or mutated. Biological differences seem to exist among different genotypes in terms of viral replication and their persistence.Questo articolo è pubblicato sotto una Licenza Licenza Creative Commons
