We aimed to validate the Nine Hole Peg Test as a measure of dexterity in myotonic dystrophy type 1 (DM1). Fifty patients with adult onset, genetically confirmed DM1 were evaluated by Nine Hole Peg Test and re-evaluated at one week. Myotonia was not a limiting factor. The first test was compared with that performed by normal subjects (n =28). Contextually, patients underwent handgrip and three-finger pinch assessments by handheld dynamometer. The Nine Hole Peg Test showed high infra-rater and inter-rater reliability in DM1 [ICC 0.86/0.83 for dominant and 0.90/0.88 for non-dominant hand, respectively]. Inverse correlation with handgrip and pinch strength values (r=0.4; p < 0.01) and direct correlation with Muscular Impairment Rating Scale (r=0.4; p < 0.01) were found for both DH and NDH. The test was able to differentiate severe DM1 patients, stratified by extent of muscle impairment, from mildly affected and normal controls, with a sensitivity of 97% and 95% for dominant hand and non-dominant hand, respectively (p <0.0001). In conclusion, we showed that the Nine Hole Peg Test is a reliable, valid and sensitive test of dexterity in DM1, and that it can be considered as a candidate outcome measure to monitor natural history of disease and, possibly, therapeutic response in clinical trials. (C) 2018 Elsevier B.V. All rights reserved.

Cutelle, C., Rastelli, E., Gibellini, M., Greco, G., Frezza, E., Botta, A., et al. (2018). Validation of the Nine Hole Peg Test as a measure of dexterity in myotonic dystrophy type 1. NEUROMUSCULAR DISORDERS, 28(11), 947-951 [10.1016/j.nmd.2018.08.011].

Validation of the Nine Hole Peg Test as a measure of dexterity in myotonic dystrophy type 1

Frezza E.;Botta A.
Investigation
;
Massa R.
2018-01-01

Abstract

We aimed to validate the Nine Hole Peg Test as a measure of dexterity in myotonic dystrophy type 1 (DM1). Fifty patients with adult onset, genetically confirmed DM1 were evaluated by Nine Hole Peg Test and re-evaluated at one week. Myotonia was not a limiting factor. The first test was compared with that performed by normal subjects (n =28). Contextually, patients underwent handgrip and three-finger pinch assessments by handheld dynamometer. The Nine Hole Peg Test showed high infra-rater and inter-rater reliability in DM1 [ICC 0.86/0.83 for dominant and 0.90/0.88 for non-dominant hand, respectively]. Inverse correlation with handgrip and pinch strength values (r=0.4; p < 0.01) and direct correlation with Muscular Impairment Rating Scale (r=0.4; p < 0.01) were found for both DH and NDH. The test was able to differentiate severe DM1 patients, stratified by extent of muscle impairment, from mildly affected and normal controls, with a sensitivity of 97% and 95% for dominant hand and non-dominant hand, respectively (p <0.0001). In conclusion, we showed that the Nine Hole Peg Test is a reliable, valid and sensitive test of dexterity in DM1, and that it can be considered as a candidate outcome measure to monitor natural history of disease and, possibly, therapeutic response in clinical trials. (C) 2018 Elsevier B.V. All rights reserved.
2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - NEUROLOGIA
Settore MED/03 - GENETICA MEDICA
English
Nine Hole Peg Test; Validation; Myotonic Dystrophy type 1; Outcome measure; Dexterity; Quantitative muscle testing
Cutelle, C., Rastelli, E., Gibellini, M., Greco, G., Frezza, E., Botta, A., et al. (2018). Validation of the Nine Hole Peg Test as a measure of dexterity in myotonic dystrophy type 1. NEUROMUSCULAR DISORDERS, 28(11), 947-951 [10.1016/j.nmd.2018.08.011].
Cutelle, C; Rastelli, E; Gibellini, M; Greco, G; Frezza, E; Botta, A; Terracciano, C; Massa, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/227530
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