Supramolecular chemistry is moving into a direction in which the composition of a chemical equilibrium is no longer determined by thermodynamics but by the efficiency with which kinetic states can be populated by energy consuming processes. Herein, we show that DNA is ideally suited for programming chemically fueled dissipative self-assembly processes. Advantages of the DNA-based systems presented in this study include a perfect control over the activation site for the chemical fuel in terms of selectivity and affinity, highly selective fuel consumption that occurs exclusively in the activated complex, and a high tolerance for the presence of waste products. Finally, it is shown that chemical fuels can be used to selectively activate different functions in a system of higher complexity embedded with multiple response pathways

Del Grosso, E., Amodio, A., Ragazzon, G., Prins, L., Ricci, F. (2018). Dissipative synthetic DNA-based receptors for the transient load and release of molecular cargo. ANGEWANDTE CHEMIE [10.1002/anie.201801318].

Dissipative synthetic DNA-based receptors for the transient load and release of molecular cargo

Del Grosso, E;Ricci, F
2018-03-30

Abstract

Supramolecular chemistry is moving into a direction in which the composition of a chemical equilibrium is no longer determined by thermodynamics but by the efficiency with which kinetic states can be populated by energy consuming processes. Herein, we show that DNA is ideally suited for programming chemically fueled dissipative self-assembly processes. Advantages of the DNA-based systems presented in this study include a perfect control over the activation site for the chemical fuel in terms of selectivity and affinity, highly selective fuel consumption that occurs exclusively in the activated complex, and a high tolerance for the presence of waste products. Finally, it is shown that chemical fuels can be used to selectively activate different functions in a system of higher complexity embedded with multiple response pathways
30-mar-2018
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore CHIM/01 - CHIMICA ANALITICA
English
Con Impact Factor ISI
Del Grosso, E., Amodio, A., Ragazzon, G., Prins, L., Ricci, F. (2018). Dissipative synthetic DNA-based receptors for the transient load and release of molecular cargo. ANGEWANDTE CHEMIE [10.1002/anie.201801318].
Del Grosso, E; Amodio, A; Ragazzon, G; Prins, L; Ricci, F
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/211423
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