Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.



Tipologia: Articolo su rivista
Citazione: Hernandez, A.f., Green, J.b., Janmohamed, S., D'Agostino, R.b., Granger, C.b., Jones, N.p., et al. (2018). Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial. THE LANCET, 392(10157), 1519-1529.
IF: Con Impact Factor ISI
Lingua: English
Settore Scientifico Disciplinare: Settore MED/13 - Endocrinologia
Revisione (peer review): Esperti anonimi
Tipo: Articolo
Rilevanza: Rilevanza internazionale
Digital Object Identifier (DOI): http://dx.doi.org/10.1016/S0140-6736(18)32261-X
Stato di pubblicazione: Pubblicato
Data di pubblicazione: 2018
Titolo: Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
Autori: 
FRONTONI, SIMONA  
LAURO, DAVIDE  
mostra contributor esterni 
Autori: Hernandez, Af; Green, Jb; Janmohamed, S; D'Agostino, Rb; Granger, Cb; Jones, Np; Leiter, La; Rosenberg, Ae; Sigmon, Kn; Somerville, Mc; Thorpe, Km; Mcmurray, Jjv; Del Prato, S; Del Prato, S; Mcmurray, Jjv; D'Agostino, Rb; Granger, Cb; Hernandez, Af; Janmohamed, S; Leiter, La; Califf, Rm; Holman, R; Demets, D; Riddle, M; Goodman, S; Mcguire, D; Alexander, K; Devore, A; Melloni, C; Patel, C; Kong, D; Bloomfield, G; Roe, M; Tricoci, P; Harrison, R; Lopes, R; Mathews, R; Mehta, R; Schuyler Jones, W; Vemulapalli, S; Povsic, T; Eapen, Z; Dombrowski, K; Kolls, B; Jordan, D; Ambrosy, A; Greene, S; Mandawat, A; Shavadia, J; Cooper, L; Sharma, A; Guimaraes, P; Friedman, D; Wilson, M; Endsley, P; Gentry, T; Collier, J; Perez, K; James, K; Roush, J; Pope, C; Howell, C; Johnson, M; Bailey, M; Cole, J; Akers, T; Vandyne, B; Thomas, B; Rich, J; Bartone, S; Beaulieu, G; Brown, K; Chau, T; Christian, T; Coker, R; Greene, D; Haddock, T; Jenkins, W; Haque, G; Marquess, M; Pesarchick, J; Rethaford, R; Stone, A; Al Kawas, F; Anderson, M; Enns, R; Sinay, I; Mathieu, C; Yordanov, V; Hramiak, I; Haluzik, M; Galatius, S; Guerci, B; Nauck, M; Migdalis, I; Tan, Cbk; Kocsis, G; Giaccari, A; Lee, Mk; Munoz, Egc; Cornel, J; Birkeland, K; Pinto, M; Tirador, L; Olesinska-Mader, M; Shestakova, M; Distiller, L; Lopez-Sendon, J; Eliasson, B; Chiang, C-; Srimahachota, S; Mankovsky, B; Bethel, Ma; Dungan, K; Kosiborod, M; Alvarisqueta, A; Baldovino, J; Besada, D; Calella, P; Cantero, Mc; Castano, P; Chertkoff, A; Cuadrado, J; De Loredo, L; Dominguez, A; Espanol, Mv; Finkelstein, H; Frechtel, G; Fretes, J; Garrido Santos, N; Gonzalez, J; Litvak, M; Loureyro, J; Maffei, L; Maldonado, N; Mohr Gasparini, D; Orio, S; Perez Manghi, F; Rodriguez Papini, N; Sala, J; Schygiel, P; Sposetti, G; Ulla, M; Verra, F; Zabalua, S; Zaidman, C; Crenier, L; Debroye, C; Duyck, F; Scheen, A; Van Gaal, L; Vercammen, C; Damyanova, V; Dimitrov, S; Kovacheva, S; Lozanov, L; Margaritov, V; Mihaylova-Shumkova, R; Nikolaeva, A; Stoyanova, Z; Akhras, R; Beaudry, Y; Bedard, J; Berlingieri, J; Chehayeb, R; Cheung, S; Conway, J; Cusson, J; Della Siega, A; Dumas, R; Dzongowski, P; Ferguson, M; Gaudet, D; Grondin, F; Gupta, A; Gupta, M; Halperin, F; Houle, P-; Jones, M; Kouz, S; Kovacs, C; Landry, D; Lonn, E; O'Mahony, W; Peterson, S; Reich, D; Rosenbloom, A; St-Maurice, F; Tugwell, B; Vizel, S; Woo, V; Brychta, T; Cech, V; Dvorakova, E; Edelsberger, T; Halciakova, K; Krizova, J; Lastuvka, J; Piperek, M; Prymkova, V; Raclavska, L; Silhova, E; Urbanek, R; Vrkoc, J; Andersen, U; Bronnum-Schou, J; Hove, J; Jensen, Js; Kober, L; Kristiansen, Op; Lund, P; Melchior, T; Nyvad, O; Schou, M; Boye, A; Cadinot, D; Gouet, D; Henry, P; Kessler, L; Lalau, J-; Petit, C; Thuan, J-; Voinot, C; Vouillarmet, J; Axthelm, C; Berger, D; Bieler, T; Birkenfeld, A; Bott, J; Busch, K; Caca, K; Chevts, J; Donaubauer, T; Erlinger, R; Funke, K; Grosskopf, J; Hagenow, A; Hamann, M; Hartard, M; Heymer, P; Huppertz, W; Illies, G; Jacob, S; Jung, T; 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Lauro, D; Orsi, E; Paolisso, G; Perriello, G; Piatti, P; Pontiroli, A; Ponzani, P; Rivellese, Aa; Sesti, G; Tonolo, G; Trevisan, R; Ahn, Cw; Baik, S-; Cha, B-; Chung, C-; Jang, Hc; Kim, C-; Kim, Hs; Kim, Ij; Lee, Ey; Lee, Hw; Lee, K-; Moon, K-; Namgung, J; Park, Ks; Yoo, Sj; Yu, J; Llamas, E-B; Cervantes-Escarcega, J-; Flota-Cervera, Lf; Gonzalez-Gonzalez, Jg; Pascoe-Gonzalez, S; Pelayo-Orozco, Es; Ramirez-Diaz, S-; Saldana-Mendoza, A; Jerjes-Diaz, Cs; Torres-Colores, Jj; Vidrio-Velazquez, M; Villagordoa-Mesa, J; Beijerbacht, Hp; Groutars, Rgej; Hoek, Ba; Hoogslag, Pam; Kooy, A; Kragten, Ja; Lieverse, Ag; Swart, Hp; Viergever, Ep; Ahlqvist, J; Cooper, J; Gulseth, H; Guttormsen, G; Wium, C; Arbanil, H; Calderon, J; Camacho, L; Espinoza, Ad; Garrido, E; Luna, A; Manrique, H; Revoredo, Fm; Gonzales, Rv; Rincon, Lz; Zubiate, C; Ebo, G; Morales-Palomares, E; Arciszewska, M; Banach, M; Bijata-Bronisz, R; Derezinski, T; Gadzinski, W; Gajek, J; Klodawska, K; Krzyzagorska, E; Madej, A; Miekus, P; Opiela, J; Romanczuk, P; Siegel, A; Skokowska, E; Stankiewicz, A; Stasinska, T; Trznadel-Morawska, I; Witek, R; Aksentyev, S; Bondar, I; Demidova, I; Dreval, A; Ershova, O; Galstyan, G; Garganeeva, A; Izmozherova, N; Karetnikova, V; Kharakhulakh, M; Khokhlov, A; Kobalava, Z; Koshelskaya, O; Kosmacheva, E; Kostin, V; Koziolova, N; Kuzin, A; Lesnov, V; Lysenko, T; Markov, V; Mayorov, A; Moiseev, S; Myasoedova, S; Petunina, N; Rebrov, A; Ruyatkina, L; Samoylova, J; Sazonova, O; Shilkina, N; Sokolova, N; Vasilevskaya, O; Verbovaya, N; Vishneva, E; Vorobyev, S; Vorokhobina, N; Zanozina, O; Zhdanova, E; Zykova, T; Burgess, L; Coetzee, K; Dawood, S; Lombard, L; Makotoko, E; Moodley, R; Oosthuysen, W; Sarvan, M; Calvo Gomez, C; Cano Rodriguez, I; Castro Conde, A; Cequier Fillat, A; Cuatrecasas Cambra, G; de Alvaro Moreno, F; De Teresa Parreno, L; Delgado Lista, J; Dominguez Escribano, Jr; Duran Garcia, S; Elvira Gonzalez, J; Fernandez Rodriguez, Jm; Goday Arno, A; Gomez Huelgas, R; Gonzalez Juanatey, Jr; 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