The performance of a novel microfluidic impedance cytometer (MIC) with coplanar configuration is investigated in silico. The main feature of the device is the ability to provide accurate particle-sizing despite the well-known measurement sensitivity to particle trajectory. The working principle of the device is presented and validated by means of an original virtual laboratory providing close-to-experimental synthetic data streams. It is shown that a metric correlating with particle trajectory can be extracted from the signal traces and used to compensate the trajectory-induced error in the estimated particle size, thus reaching high-accuracy. An analysis of relevant parameters of the experimental setup is also presented.

Caselli, F., Bisegna, P. (2017). Simulation and performance analysis of a novel high-accuracy sheathless microfluidic impedance cytometer with coplanar electrode layout. MEDICAL ENGINEERING & PHYSICS, 48, 81-89 [10.1016/j.medengphy.2017.04.005].

Simulation and performance analysis of a novel high-accuracy sheathless microfluidic impedance cytometer with coplanar electrode layout

Caselli, F
;
Bisegna, P
2017-01-01

Abstract

The performance of a novel microfluidic impedance cytometer (MIC) with coplanar configuration is investigated in silico. The main feature of the device is the ability to provide accurate particle-sizing despite the well-known measurement sensitivity to particle trajectory. The working principle of the device is presented and validated by means of an original virtual laboratory providing close-to-experimental synthetic data streams. It is shown that a metric correlating with particle trajectory can be extracted from the signal traces and used to compensate the trajectory-induced error in the estimated particle size, thus reaching high-accuracy. An analysis of relevant parameters of the experimental setup is also presented.
2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore ING-IND/34 - BIOINGEGNERIA INDUSTRIALE
Settore ICAR/08 - SCIENZA DELLE COSTRUZIONI
English
Coplanar electrodes; microfluidic impedance cytometry; modeling and simulation; particle sizing; cytological techniques; electric impedance; electrodes; equipment design; microspheres; particle size; finite element analysis; Lab-on-a-chip devices
Caselli, F., Bisegna, P. (2017). Simulation and performance analysis of a novel high-accuracy sheathless microfluidic impedance cytometer with coplanar electrode layout. MEDICAL ENGINEERING & PHYSICS, 48, 81-89 [10.1016/j.medengphy.2017.04.005].
Caselli, F; Bisegna, P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/200786
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