A novel fluid-structure computational framework for vascular applications is herein presented. It is de- veloped by combining the double multi-scale nature of vascular physiopathology in terms of both tis- sue properties and blood flow. Addressing arterial tissues, they are modelled via a nonlinear multiscale constitutive rationale, based only on parameters having a clear histological and biochemical meaning. Moreover, blood flow is described by coupling a three-dimensional fluid domain (undergoing physiolog- ical inflow conditions) with a zero-dimensional model, which allows to reproduce the influence of the downstream vasculature, furnishing a realistic description of the outflow proximal pressure. The fluid- structure interaction is managed through an explicit time-marching approach, able to accurately describe tissue nonlinearities within each computational step for the fluid problem. A case study associated to a patient-specific aortic abdominal aneurysmatic geometry is numerically investigated, highlighting advan- tages gained from the proposed multiscale strategy, as well as showing soundness and effectiveness of the established framework for assessing useful clinical quantities and risk indexes.

Bianchi, D., Monaldo, E., Gizzi, A., Marino, M., Filippi, S., & Vairo, G. (2017). A FSI computational framework for vascular physiopathology: a novel flow-tissue multiscale strategy. MEDICAL ENGINEERING & PHYSICS, 47, 25-37 [10.1016/j.medengphy.2017.06.028].

A FSI computational framework for vascular physiopathology: a novel flow-tissue multiscale strategy

Bianchi, D;Marino, M;Vairo, G
2017

Abstract

A novel fluid-structure computational framework for vascular applications is herein presented. It is de- veloped by combining the double multi-scale nature of vascular physiopathology in terms of both tis- sue properties and blood flow. Addressing arterial tissues, they are modelled via a nonlinear multiscale constitutive rationale, based only on parameters having a clear histological and biochemical meaning. Moreover, blood flow is described by coupling a three-dimensional fluid domain (undergoing physiolog- ical inflow conditions) with a zero-dimensional model, which allows to reproduce the influence of the downstream vasculature, furnishing a realistic description of the outflow proximal pressure. The fluid- structure interaction is managed through an explicit time-marching approach, able to accurately describe tissue nonlinearities within each computational step for the fluid problem. A case study associated to a patient-specific aortic abdominal aneurysmatic geometry is numerically investigated, highlighting advan- tages gained from the proposed multiscale strategy, as well as showing soundness and effectiveness of the established framework for assessing useful clinical quantities and risk indexes.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore ICAR/08 - Scienza delle Costruzioni
eng
Con Impact Factor ISI
Multiscale tissue mechanics; Nonlinear material modeling; Fluid-structure interaction; Abdominal aortic aneurysm; Wall shear stress Hemodynamic risk indexes
Bianchi, D., Monaldo, E., Gizzi, A., Marino, M., Filippi, S., & Vairo, G. (2017). A FSI computational framework for vascular physiopathology: a novel flow-tissue multiscale strategy. MEDICAL ENGINEERING & PHYSICS, 47, 25-37 [10.1016/j.medengphy.2017.06.028].
Bianchi, D; Monaldo, E; Gizzi, A; Marino, M; Filippi, S; Vairo, G
Articolo su rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/200496
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 20
social impact