Chronic noncommunicable diseases (NCDs) are the leading causes of disability and death worldwide. NCDs mainly comprise diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, cancer, and neurological degenerative diseases, which kill more than 80% of population, especially the elderly, worldwide. Recent Advances: Several recent theories established NCDs as multifactorial diseases, where a combination of genetic, epigenetic, and environmental factors contributes to their pathogenesis. Nevertheless, recent findings suggest that the common factor linking all these pathologies is an increase in oxidative stress and the age-related loss of the antioxidant mechanisms of defense against it. Impairment in mitochondrial homeostasis with consequent deregulation in oxidative stress balance has also been suggested.

Pacifici, F., Della Morte, D., Capuani, B., Pastore, D., Bellia, A., Sbraccia, P., et al. (2019). Peroxiredoxin6, a Multitask Antioxidant Enzyme Involved in the Pathophysiology of Chronic Noncommunicable Diseases. ANTIOXIDANTS & REDOX SIGNALING, 30(3), 399-414 [10.1089/ars.2017.7427].

Peroxiredoxin6, a Multitask Antioxidant Enzyme Involved in the Pathophysiology of Chronic Noncommunicable Diseases

PACIFICI, FRANCESCA;Della Morte, David;Capuani, Barbara;Pastore, Donatella;Bellia, Alfonso;Sbraccia, Paolo;Di Daniele, Nicola;Lauro, Renato;Lauro, Davide
2019

Abstract

Chronic noncommunicable diseases (NCDs) are the leading causes of disability and death worldwide. NCDs mainly comprise diabetes mellitus, cardiovascular diseases, chronic obstructive pulmonary disease, cancer, and neurological degenerative diseases, which kill more than 80% of population, especially the elderly, worldwide. Recent Advances: Several recent theories established NCDs as multifactorial diseases, where a combination of genetic, epigenetic, and environmental factors contributes to their pathogenesis. Nevertheless, recent findings suggest that the common factor linking all these pathologies is an increase in oxidative stress and the age-related loss of the antioxidant mechanisms of defense against it. Impairment in mitochondrial homeostasis with consequent deregulation in oxidative stress balance has also been suggested.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/13 - Endocrinologia
Settore MED/09 - Medicina Interna
English
antioxidant; peroxiredoxin6; senescence; type 2 diabetes mellitus
Pacifici, F., Della Morte, D., Capuani, B., Pastore, D., Bellia, A., Sbraccia, P., et al. (2019). Peroxiredoxin6, a Multitask Antioxidant Enzyme Involved in the Pathophysiology of Chronic Noncommunicable Diseases. ANTIOXIDANTS & REDOX SIGNALING, 30(3), 399-414 [10.1089/ars.2017.7427].
Pacifici, F; Della Morte, D; Capuani, B; Pastore, D; Bellia, A; Sbraccia, P; Di Daniele, N; Lauro, R; Lauro, D
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/192214
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