Life-long prophylaxis against HBV recurrence is recommended in patients transplanted for HBV-related disease. The risk of HBV reactivation is due to persistence of covalently closed circular (ccc) DNA in hepatocytes. Whether cccDNA persists in livers of long-term transplant survivors who received conventional prophylaxis is unknown.
Lenci, I., Marcuccilli, F., Tisone, G., Di Paolo, D., Tariciotti, L., Ciotti, M., et al. (2010). Total and covalently closed circular DNA detection in liver tissue of long-term survivors transplanted for HBV-related cirrhosis. DIGESTIVE AND LIVER DISEASE, 42(8), 578-584 [10.1016/j.dld.2009.12.003].
Total and covalently closed circular DNA detection in liver tissue of long-term survivors transplanted for HBV-related cirrhosis
TISONE, GIUSEPPE;PERNO, CARLO FEDERICO;ANGELICO, MARIO
2010-01-01
Abstract
Life-long prophylaxis against HBV recurrence is recommended in patients transplanted for HBV-related disease. The risk of HBV reactivation is due to persistence of covalently closed circular (ccc) DNA in hepatocytes. Whether cccDNA persists in livers of long-term transplant survivors who received conventional prophylaxis is unknown.File in questo prodotto:
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