The chemokine CCL20 is over-produced in epithelium of Crohn's disease [CD] patients and contributes to recruiting immune cells to inflamed gut. Tumour necrosis factor-α [TNF-α] is a powerful inducer of CCL20 in intestinal epithelial cells. In CD, high levels of Smad7 block the activity of transforming growth factor-β1 [TGF-β1], a negative regulator of TNF signalling. We investigated whether intestinal epithelial cell-derived CCL20 is negatively regulated by TGF-β1 and whether Smad7 knock-down reduces CCL20 in CD.

Marafini, I., Monteleone, I., Dinallo, V., Di Fusco, D., DE SIMONE, V., Laudisi, F., et al. (2017). CCL20 Is Negatively Regulated by TGF-β1 in Intestinal Epithelial Cells and Reduced in Crohn's Disease Patients With a Successful Response to Mongersen, a Smad7 Antisense Oligonucleotide. JOURNAL OF CROHN'S AND COLITIS, 11(5), 603-609 [10.1093/ecco-jcc/jjw191].

CCL20 Is Negatively Regulated by TGF-β1 in Intestinal Epithelial Cells and Reduced in Crohn's Disease Patients With a Successful Response to Mongersen, a Smad7 Antisense Oligonucleotide

MARAFINI, IRENE;MONTELEONE, IVAN;DINALLO, VINCENZO;DE SIMONE, VERONICA;FANTINI, MASSIMO CLAUDIO;PALLONE, FRANCESCO;MONTELEONE, GIOVANNI
2017-01-01

Abstract

The chemokine CCL20 is over-produced in epithelium of Crohn's disease [CD] patients and contributes to recruiting immune cells to inflamed gut. Tumour necrosis factor-α [TNF-α] is a powerful inducer of CCL20 in intestinal epithelial cells. In CD, high levels of Smad7 block the activity of transforming growth factor-β1 [TGF-β1], a negative regulator of TNF signalling. We investigated whether intestinal epithelial cell-derived CCL20 is negatively regulated by TGF-β1 and whether Smad7 knock-down reduces CCL20 in CD.
2017
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/12 - GASTROENTEROLOGIA
English
IBD; Mip-3α; TGF-β
Marafini, I., Monteleone, I., Dinallo, V., Di Fusco, D., DE SIMONE, V., Laudisi, F., et al. (2017). CCL20 Is Negatively Regulated by TGF-β1 in Intestinal Epithelial Cells and Reduced in Crohn's Disease Patients With a Successful Response to Mongersen, a Smad7 Antisense Oligonucleotide. JOURNAL OF CROHN'S AND COLITIS, 11(5), 603-609 [10.1093/ecco-jcc/jjw191].
Marafini, I; Monteleone, I; Dinallo, V; Di Fusco, D; DE SIMONE, V; Laudisi, F; Fantini, Mc; Di Sabatino, A; Pallone, F; Monteleone, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/174659
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