Protein function is often dependent on subsets of solvent-exposed residues that may exist in a similar three-dimensional configuration in non homologous proteins thus having different order and/or spacing in the sequence. Hence, functional annotation by means of sequence or fold similarity is not adequate for such cases.
Ferrè, F., Ausiello, G., Zanzoni, A., HELMER CITTERICH, M. (2005). Functional annotation by identification of local surface similarities: a novel tool for structural genomics. BMC BIOINFORMATICS, 6, 194 [10.1186/1471-2105-6-194].
Functional annotation by identification of local surface similarities: a novel tool for structural genomics
AUSIELLO, GABRIELE;HELMER CITTERICH, MANUELA
2005-08-02
Abstract
Protein function is often dependent on subsets of solvent-exposed residues that may exist in a similar three-dimensional configuration in non homologous proteins thus having different order and/or spacing in the sequence. Hence, functional annotation by means of sequence or fold similarity is not adequate for such cases.File in questo prodotto:
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