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EnglishThe SH3 domain family is one of the most representative and widely studied cases of so-called Peptide Recognition Modules (PRM). The polyproline II motif PxxP that generally characterizes its ligands does not reflect the complex interaction spectrum of the over 1500 different SH3 domains, and the requirement of a more refined knowledge of their specificity implies the setting up of appropriate experimental and theoretical strategies. Due to the limitations of the current technology for peptide synthesis, several experimental high-throughput approaches have been devised to elucidate protein-protein interaction mechanisms. Such approaches can rely on and take advantage of computational techniques, such as regular expressions or position specific scoring matrices (PSSMs) to pre-process entire proteomes in the search for putative SH3 targets. In this regard, a reliable inference methodology to be used for reducing the sequence space of putative binding peptides represents a valuable support for molecular and cellular biologists.
Ferraro, E., Via, A., Ausiello, G., & Helmer-Citterich, M. (2005). A neural strategy for the inference of SH3 domain-peptide interaction specificity. BMC BIOINFORMATICS, 6 Suppl 4(6), S13 [10.1186/1471-2105-6-S4-S13].
| Tipologia: | Articolo su rivista | |
| Citazione: | Ferraro, E., Via, A., Ausiello, G., & Helmer-Citterich, M. (2005). A neural strategy for the inference of SH3 domain-peptide interaction specificity. BMC BIOINFORMATICS, 6 Suppl 4(6), S13 [10.1186/1471-2105-6-S4-S13]. | |
| URL: | http://www.biomedcentral.com/1471-2105/6/S4/S13 | |
| IF: | Con Impact Factor ISI | |
| Lingua: | English | |
| Settore Scientifico Disciplinare: | Settore BIO/11 | |
| Revisione (peer review): | Sì, ma tipo non specificato | |
| Tipo: | Articolo | |
| Rilevanza: | Rilevanza internazionale | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1186/1471-2105-6-S4-S13 | |
| Stato di pubblicazione: | Pubblicato | |
| Data di pubblicazione: | 1-dic-2005 | |
| Titolo: | A neural strategy for the inference of SH3 domain-peptide interaction specificity | |
| Autori: | ||
| Autori: | Ferraro, E; Via, A; Ausiello, G; Helmer-Citterich, M | |
| Appare nelle tipologie: | 01 - Articolo su rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Ferraro_etal_2005.pdf | research article | N/A | Open Access Visualizza/Apri |
http://hdl.handle.net/2108/15262
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