False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a numerical approach to investigate the random appearance of functional motifs with the aim of addressing biological questions such as: How are organisms protected from undesirable occurrences of motifs otherwise selected for their functionality? Has the random appearance of functional motifs in protein sequences been affected during evolution?
Via, A., Gherardini, P., Ferraro, E., Ausiello, G., SCALIA TOMBA, G., HELMER CITTERICH, M. (2007). False occurrences of functional motifs in protein sequences highlight evolutionary constraints. BMC BIOINFORMATICS, 8(1), 68 [10.1186/1471-2105-8-68].
False occurrences of functional motifs in protein sequences highlight evolutionary constraints
Gherardini, PF;AUSIELLO, GABRIELE;SCALIA TOMBA, GIANPAOLO;HELMER CITTERICH, MANUELA
2007-03-01
Abstract
False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a numerical approach to investigate the random appearance of functional motifs with the aim of addressing biological questions such as: How are organisms protected from undesirable occurrences of motifs otherwise selected for their functionality? Has the random appearance of functional motifs in protein sequences been affected during evolution?| File | Dimensione | Formato | |
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