The occurrence of very similar structural motifs brought about by different parts of non homologous proteins is often indicative of a common function. Indeed, relatively small local structures can mediate binding to a common partner, be it a protein, a nucleic acid, a cofactor or a substrate. While it is relatively easy to identify short amino acid or nucleotide sequence motifs in a given set of proteins or genes, and many methods do exist for this purpose, much more challenging is the identification of common local substructures, especially if they are formed by non consecutive residues in the sequence.
Ausiello, G., Gherardini, P.F., Marcatili, P., Tramontano, A., Via, A., & Helmer-Citterich, M. (2008). FunClust: a web server for the identification of structural motifs in a set of non-homologous protein structures. BMC BIOINFORMATICS, 9 Suppl 2, S2.
Tipologia: | Articolo su rivista |
Citazione: | Ausiello, G., Gherardini, P.F., Marcatili, P., Tramontano, A., Via, A., & Helmer-Citterich, M. (2008). FunClust: a web server for the identification of structural motifs in a set of non-homologous protein structures. BMC BIOINFORMATICS, 9 Suppl 2, S2. |
Lingua: | English |
Settore Scientifico Disciplinare: | Settore BIO/11 |
Revisione (peer review): | Sì, ma tipo non specificato |
Tipo: | Articolo |
Rilevanza: | Rilevanza internazionale |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1186/1471-2105-9-S2-S2 |
Stato di pubblicazione: | Pubblicato |
Data di pubblicazione: | 2008 |
Titolo: | FunClust: a web server for the identification of structural motifs in a set of non-homologous protein structures |
Autori: | |
Autori: | Ausiello, G; Gherardini, PF; Marcatili, P; Tramontano, A; Via, A; Helmer-Citterich, M |
Appare nelle tipologie: | 01 - Articolo su rivista |
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