The occurrence of very similar structural motifs brought about by different parts of non homologous proteins is often indicative of a common function. Indeed, relatively small local structures can mediate binding to a common partner, be it a protein, a nucleic acid, a cofactor or a substrate. While it is relatively easy to identify short amino acid or nucleotide sequence motifs in a given set of proteins or genes, and many methods do exist for this purpose, much more challenging is the identification of common local substructures, especially if they are formed by non consecutive residues in the sequence.

Ausiello, G., Gherardini, P., Marcatili, P., Tramontano, A., Via, A., HELMER CITTERICH, M. (2008). FunClust: a web server for the identification of structural motifs in a set of non-homologous protein structures. BMC BIOINFORMATICS, 9 Suppl 2, S2 [10.1186/1471-2105-9-S2-S2].

FunClust: a web server for the identification of structural motifs in a set of non-homologous protein structures

AUSIELLO, GABRIELE;Gherardini, PF;HELMER CITTERICH, MANUELA
2008-01-01

Abstract

The occurrence of very similar structural motifs brought about by different parts of non homologous proteins is often indicative of a common function. Indeed, relatively small local structures can mediate binding to a common partner, be it a protein, a nucleic acid, a cofactor or a substrate. While it is relatively easy to identify short amino acid or nucleotide sequence motifs in a given set of proteins or genes, and many methods do exist for this purpose, much more challenging is the identification of common local substructures, especially if they are formed by non consecutive residues in the sequence.
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/11
English
Sequence Homology, Amino Acid; Sequence Analysis, Protein; Amino Acid Motifs; Proteins; Pattern Recognition, Automated; Molecular Sequence Data; Software; Sequence Alignment; Internet; Amino Acid Sequence; Cluster Analysis
Ausiello, G., Gherardini, P., Marcatili, P., Tramontano, A., Via, A., HELMER CITTERICH, M. (2008). FunClust: a web server for the identification of structural motifs in a set of non-homologous protein structures. BMC BIOINFORMATICS, 9 Suppl 2, S2 [10.1186/1471-2105-9-S2-S2].
Ausiello, G; Gherardini, P; Marcatili, P; Tramontano, A; Via, A; HELMER CITTERICH, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/15050
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