Ultrasound contrast agents (UCAs) have been used routinely in clinical diagnostics. The most used UCA is a saline suspension of lipid shells with a stabilizing hydrophobic gas core. However, focus on other UCAs have been also considered so far, including shells made of high molecular weight moieties. Polymer based shells1 provide a unique platform supporting multimodality2 (US, MRI for example) and multifunctionality3 (targeting, theranostics). The endurance of the polymer shells allows a long circulation life, although this feature can decrease the microbubble echogenicity. Bearing in mind such hurdles, this contribution will highlight the potentialities of polymer shelled microbubbles in supporting fast developing new methodologies such as photoacoustic imaging. It will also illustrate how “crosslinked polymer shells” concept can be advantageously used in the field of the “phase shift” microsystems.4 Insonification can transform microdroplets having crosslinked polymer shell into ultrasound active microbubbles via acoustic droplet vaporization (ADV). The viscoelasticity of the shell controls the expansion of the microbubble shell and is responsible for its return to the original droplet state in a time lapse of some minutes. The analysis of the time dependence of this retraction process provides an insight of the microrheology parameters of the polymer shell.5 References: 1 F. Cavalieri, A. El Hamassi, E. Chiessi, G. Paradossi. Langmuir, , 21, 8758-8764 (2005) 2 T. B. Brismar, D. Grishenkov, B. Gustafsson, J. Härmark, Å. Barrefelt, S. V. V. N. Kothapalli, S. Margheritelli, L. Oddo, K. Caidahl, H. Hebert and G. Paradossi. Biomacromolecules 13 (5), 1390–1399 (2012) 3 R. Villa, B. Cerroni, L. Viganò, S. Margheritelli, G. Abolafio, L. Oddo, G. Paradossi, N. Zaffaroni Colloids and Surfaces B: Biointerfaces 110, 434 – 442 (2013) 4 S. Capece, E. Chiessi, R. Cavalli, P. Giustetto, D. Grishenkov, G. Paradossi. Chem. Commun., 49, 5763 - 5765 (2013) 5 S. Capece, F. Domenici, F. Brasili, L. Oddo, B. Cerroni, A. Bedini, F. Bordi, E. Chiessi, G. Paradossi, to be submitted (2015)
Paradossi, G. (2016). Echogenic polymer platforms: toward a versatile diagnostic tool. ??????? it.cilea.surplus.oa.citation.tipologie.CitationProceedings.prensentedAt ??????? The 21st European Symposium on Ultrasound Contrast Imaging - An ICUS Conference -, Rotterdam.
Echogenic polymer platforms: toward a versatile diagnostic tool
PARADOSSI, GAIO
2016-01-01
Abstract
Ultrasound contrast agents (UCAs) have been used routinely in clinical diagnostics. The most used UCA is a saline suspension of lipid shells with a stabilizing hydrophobic gas core. However, focus on other UCAs have been also considered so far, including shells made of high molecular weight moieties. Polymer based shells1 provide a unique platform supporting multimodality2 (US, MRI for example) and multifunctionality3 (targeting, theranostics). The endurance of the polymer shells allows a long circulation life, although this feature can decrease the microbubble echogenicity. Bearing in mind such hurdles, this contribution will highlight the potentialities of polymer shelled microbubbles in supporting fast developing new methodologies such as photoacoustic imaging. It will also illustrate how “crosslinked polymer shells” concept can be advantageously used in the field of the “phase shift” microsystems.4 Insonification can transform microdroplets having crosslinked polymer shell into ultrasound active microbubbles via acoustic droplet vaporization (ADV). The viscoelasticity of the shell controls the expansion of the microbubble shell and is responsible for its return to the original droplet state in a time lapse of some minutes. The analysis of the time dependence of this retraction process provides an insight of the microrheology parameters of the polymer shell.5 References: 1 F. Cavalieri, A. El Hamassi, E. Chiessi, G. Paradossi. Langmuir, , 21, 8758-8764 (2005) 2 T. B. Brismar, D. Grishenkov, B. Gustafsson, J. Härmark, Å. Barrefelt, S. V. V. N. Kothapalli, S. Margheritelli, L. Oddo, K. Caidahl, H. Hebert and G. Paradossi. Biomacromolecules 13 (5), 1390–1399 (2012) 3 R. Villa, B. Cerroni, L. Viganò, S. Margheritelli, G. Abolafio, L. Oddo, G. Paradossi, N. Zaffaroni Colloids and Surfaces B: Biointerfaces 110, 434 – 442 (2013) 4 S. Capece, E. Chiessi, R. Cavalli, P. Giustetto, D. Grishenkov, G. Paradossi. Chem. Commun., 49, 5763 - 5765 (2013) 5 S. Capece, F. Domenici, F. Brasili, L. Oddo, B. Cerroni, A. Bedini, F. Bordi, E. Chiessi, G. Paradossi, to be submitted (2015)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
