Recent evidence suggests that natural killer (NK) cells are typically defective in infiltrating solid tumors, with the exception of gastrointestinal stromal tumors (GIST). Interestingly, however, infrequently infiltrating NK cells do not appear to have a direct effect on tumor progression. Here, prompted by the recent evidence that NK cell and T cell crosstalk may trigger, or enhance, tumor antigen-specific immune responses, we have tested the clinical significance of this reciprocal signaling. To this end, a tissue microarray constructed with 1410 colorectal carcinoma (CRC) patient specimens was stained with NK and T cell antigen-specific monoclonal antibodies, utilizing the immunoperoxidase staining technique. Cut-off scores for positive (>4 NK cells) and negative (≤4 NK cells) NK cell CRC patient samples were determined using receiver operating characteristic curve analysis. Using this approach, NK cells were detected in 423 (30%) of the 1410 CRC specimens evaluated. The number of NK cells was >4 in only 132 (9%) of CRC samples. Correlation of the immunohistochemical staining results together with analysis of the clinical course of the disease revealed that the infiltration of colorectal tumors with both NK cells and CD8+ T cells is associated with prolonged patient survival. In contrast, infiltration of tumors with NK cells in combination with CD3(+) and CD4(+) T lymphocytes had no detectable effect on the clinical course of the disease. These results suggest that NK cell and CD8(+) T cell crosstalk in the tumor microenvironment may benefit patient outcome and further, that the enumeration of infiltrating NK and CD8(+) T cells in CRC tumors may provide useful prognostic information.
|Tipologia:||Articolo su rivista|
|Citazione:||Sconocchia, G., Eppenberger, S., Spagnoli, G.c., Tornillo, L., Droeser, R., Caratelli, S., et al. (2014). NK cells and T cells cooperate during the clinical course of colorectal cancer. ONCOIMMUNOLOGY, 3(8), e952197.|
|IF:||Con Impact Factor ISI|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
Settore MED/09 - Medicina Interna
|Revisione (peer review):||Esperti anonimi|
|Digital Object Identifier (DOI):||10.4161/21624011.2014.952197|
|Stato di pubblicazione:||Pubblicato|
|Data di pubblicazione:||2014|
|Titolo:||NK cells and T cells cooperate during the clinical course of colorectal cancer|
|Autori interni:||FERRELLI, FRANCESCA |
|Autori:||Sconocchia, G; Eppenberger, S; Spagnoli, Gc; Tornillo, L; Droeser, R; Caratelli, S; Ferrelli, F; Coppola, A; Arriga, R; Lauro, D; Iezzi, G; Terracciano, L; Ferrone, S|
|Appare nelle tipologie:||01 - Articolo su rivista|
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