We investigate a control method for malaria dynamics to boost the immune response using a model-based approach. The idea of state jump is introduced and discussed using a hybrid model. To implement the state jumps we use a physiologically feasible method for the biological system, whereby the introduction of a pathogen into the system steers it to a desirable status. It is noted that we take advantage of a pathogen to implement state jumps in the system. The study is supported by recently reported experimental results.
Chang, H., Astolfi, A., Shim, H. (2011). A control theoretic approach to malaria immunotherapy with state jumps. AUTOMATICA, 47(6), 1271-1277 [10.1016/j.automatica.2011.03.009].
A control theoretic approach to malaria immunotherapy with state jumps
ASTOLFI, ALESSANDRO;
2011-06-01
Abstract
We investigate a control method for malaria dynamics to boost the immune response using a model-based approach. The idea of state jump is introduced and discussed using a hybrid model. To implement the state jumps we use a physiologically feasible method for the biological system, whereby the introduction of a pathogen into the system steers it to a desirable status. It is noted that we take advantage of a pathogen to implement state jumps in the system. The study is supported by recently reported experimental results.| File | Dimensione | Formato | |
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