Diabetes often correlates with tau phosphorylation and the development of Alzheimer's disease. Both are associated with brain cholinergic dysfunction that could benefit from nerve growth factor (NGF)-based therapies. Electroacupuncture (EA) improves brain NGF availability and action. Here we assessed the variations of NGF and tau phosphorylation in the cortex and hippocampus, as well as the expression of choline acetyltransferase in the basal forebrain following diabetes induction and EA in adult rats. We found that EA counteracts diabetes-associated tau hyperphosphorylation and decreases in NGF and choline acetyltransferase, suggesting a possible beneficial effect of EA on brain cholinergic system in diabetes.

Rocco, M., Pristerà, A., Pistillo, L., Aloe, L., Canu, N., Manni, L. (2013). Brain cholinergic markers and Tau phosphorylation are altered in experimental type 1 diabetes: normalization by electroacupuncture. JOURNAL OF ALZHEIMER'S DISEASE, 33(3), 767-773 [10.3233/JAD-2012-121309].

Brain cholinergic markers and Tau phosphorylation are altered in experimental type 1 diabetes: normalization by electroacupuncture.

CANU, NADIA
;
2013-01-01

Abstract

Diabetes often correlates with tau phosphorylation and the development of Alzheimer's disease. Both are associated with brain cholinergic dysfunction that could benefit from nerve growth factor (NGF)-based therapies. Electroacupuncture (EA) improves brain NGF availability and action. Here we assessed the variations of NGF and tau phosphorylation in the cortex and hippocampus, as well as the expression of choline acetyltransferase in the basal forebrain following diabetes induction and EA in adult rats. We found that EA counteracts diabetes-associated tau hyperphosphorylation and decreases in NGF and choline acetyltransferase, suggesting a possible beneficial effect of EA on brain cholinergic system in diabetes.
2013
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore BIO/09 - FISIOLOGIA
English
Con Impact Factor ISI
Rocco, M., Pristerà, A., Pistillo, L., Aloe, L., Canu, N., Manni, L. (2013). Brain cholinergic markers and Tau phosphorylation are altered in experimental type 1 diabetes: normalization by electroacupuncture. JOURNAL OF ALZHEIMER'S DISEASE, 33(3), 767-773 [10.3233/JAD-2012-121309].
Rocco, M; Pristerà, A; Pistillo, L; Aloe, L; Canu, N; Manni, L
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/103433
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