Twelve-hour nocturnal GH secretion was studied in 30 children with familial short stature (FSS), constitutional growth delay (CGD), total growth hormone deficiency (TGHD), partial growth hormone deficiency (PGHD), or idiopathic short stature (ISS). No difference was observed between subjects with FSS and children with CGD. The mean 12-hour serum GH concentration was significantly lower in patients with TGHD (p less than 0.001), children with PGHD (p less than 0.01), and subjects with ISS (p less than 0.01) than in subjects with FSS and CGD. No overlap was observed between the range of mean concentration values of children with TGHD and that of subjects with FSS. A significant correlation was found between growth velocity expressed as SD from the mean for bone age and GH concentration (p less than 0.001). All patients with a growth velocity less than 3rd percentile for bone age showed a mean nocturnal concentration less than 4 ng/ml. These data suggest that evaluation of 12-hour spontaneous nocturnal GH secretion with GH sampling every 30 minutes can be usefully employed in the diagnosis of GH deficiency.

Spadoni, G.l., Cianfarani, S., Bernardini, S., Vaccaro, F., Galasso, C., MANCA BITTI, M.l., et al. (1988). Twelve-hour spontaneous nocturnal growth hormone secretion in growth retarded patients, 27(10), 473-478.

Twelve-hour spontaneous nocturnal growth hormone secretion in growth retarded patients

SPADONI, GIAN LUIGI;CIANFARANI, STEFANO;BERNARDINI, SERGIO;GALASSO, CINZIA;MANCA BITTI, MARIA LUISA;BOSCHERINI, BRUNETTO
1988-10-01

Abstract

Twelve-hour nocturnal GH secretion was studied in 30 children with familial short stature (FSS), constitutional growth delay (CGD), total growth hormone deficiency (TGHD), partial growth hormone deficiency (PGHD), or idiopathic short stature (ISS). No difference was observed between subjects with FSS and children with CGD. The mean 12-hour serum GH concentration was significantly lower in patients with TGHD (p less than 0.001), children with PGHD (p less than 0.01), and subjects with ISS (p less than 0.01) than in subjects with FSS and CGD. No overlap was observed between the range of mean concentration values of children with TGHD and that of subjects with FSS. A significant correlation was found between growth velocity expressed as SD from the mean for bone age and GH concentration (p less than 0.001). All patients with a growth velocity less than 3rd percentile for bone age showed a mean nocturnal concentration less than 4 ng/ml. These data suggest that evaluation of 12-hour spontaneous nocturnal GH secretion with GH sampling every 30 minutes can be usefully employed in the diagnosis of GH deficiency.
ott-1988
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
English
Con Impact Factor ISI
Humans; Growth Disorders; Child; Adolescent; Time Factors; Male; Female; Growth Hormone
Spadoni, G.l., Cianfarani, S., Bernardini, S., Vaccaro, F., Galasso, C., MANCA BITTI, M.l., et al. (1988). Twelve-hour spontaneous nocturnal growth hormone secretion in growth retarded patients, 27(10), 473-478.
Spadoni, Gl; Cianfarani, S; Bernardini, S; Vaccaro, F; Galasso, C; MANCA BITTI, Ml; Costa, F; Boscherini, B
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/103012
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