A total of 21 patients with somatotropic deficiency have been enrolled in a clinical trial of biosynthetic growth hormone (bio-GH) and pituitary growth hormone (pit-GH). Five of them not previously treated (naïve) and 7 previously treated with pit-GH, received bio-GH; 9 received only pit-GH. Biosynthetic-GH was given 12 UI/m2/week. Height velocities during treatment rose, for naïve patients, from 3.6 +/- 0.3 cm/year (before treatment) to 8.7 +/- 1.3 cm/year (after 12 months treatment). For previously treated patients, after a period at least 6 months without any GH therapy, the increase in height was from 2.5 +/- 0.9 cm/year to 6.8 cm/year; and for the patients who received only pit-GH was from 3.4 +/- 1.2 cm/year to 8.0 +/- 1.1 cm/year. No significant difference was observed between the growth velocities obtained with the two preparations. No specific side-effects were noted.

Spagnoli, A., Bernardini, S., Galasso, C., Vaccaro, F., MANCA BITTI, M.l., Scire', G., et al. (1989). [Treatment of somatotropic deficiency with biosynthetic growth hormone]. PEDIATRIA MEDICA E CHIRURGICA, 11(4), 413-418.

[Treatment of somatotropic deficiency with biosynthetic growth hormone]

BERNARDINI, SERGIO;GALASSO, CINZIA;MANCA BITTI, MARIA LUISA;SCIRE', GIUSEPPE;CIANFARANI, STEFANO;SPADONI, GIAN LUIGI
1989-01-01

Abstract

A total of 21 patients with somatotropic deficiency have been enrolled in a clinical trial of biosynthetic growth hormone (bio-GH) and pituitary growth hormone (pit-GH). Five of them not previously treated (naïve) and 7 previously treated with pit-GH, received bio-GH; 9 received only pit-GH. Biosynthetic-GH was given 12 UI/m2/week. Height velocities during treatment rose, for naïve patients, from 3.6 +/- 0.3 cm/year (before treatment) to 8.7 +/- 1.3 cm/year (after 12 months treatment). For previously treated patients, after a period at least 6 months without any GH therapy, the increase in height was from 2.5 +/- 0.9 cm/year to 6.8 cm/year; and for the patients who received only pit-GH was from 3.4 +/- 1.2 cm/year to 8.0 +/- 1.1 cm/year. No significant difference was observed between the growth velocities obtained with the two preparations. No specific side-effects were noted.
1989
Pubblicato
Rilevanza nazionale
Articolo
Sì, ma tipo non specificato
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA
Italian
Body Height; Humans; Clinical Trials as Topic; Child; Hormones; Child, Preschool; Infant; Drug Evaluation; Growth Disorders; Adolescent; Female; Male; Growth Hormone
Spagnoli, A., Bernardini, S., Galasso, C., Vaccaro, F., MANCA BITTI, M.l., Scire', G., et al. (1989). [Treatment of somatotropic deficiency with biosynthetic growth hormone]. PEDIATRIA MEDICA E CHIRURGICA, 11(4), 413-418.
Spagnoli, A; Bernardini, S; Galasso, C; Vaccaro, F; MANCA BITTI, Ml; Scire', G; Cianfarani, S; Spadoni, Gl
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/103011
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