Calcium-channel entry blockers are drugs with different chemical properties and a common pharmacological characteristic. Calcium is very important in many physiological mechanisms and could be involved in neuronal damage following cerebral ischemia. Thus, calcium-channel blockers agents could be of interest in medical treatment of cerebrovascular diseases, headache and subarachnoid hemorrhage. Calcium-channel blockers seem to have a direct protective role against neuronal ischemic damage and/or a direct action on cerebral vessels. Some clinical experiences have suggested a protective role of nimodipine in the prevention of ischemic complications related to cerebral vasospasm after subarachnoid hemorrhage.

Govoni, S., Trabucchi, M.m., Battaini, F.m., Magnoni, M., Paoletti, R. (1986). [Vascular and neuronal mechanisms of calcium antagonists. Significance in neurological therapy]. MINERVA MEDICA, 77(24), 1053-1058.

[Vascular and neuronal mechanisms of calcium antagonists. Significance in neurological therapy]

TRABUCCHI, MARCO MARIO;BATTAINI, FIORENZO MARIA;
1986-06-08

Abstract

Calcium-channel entry blockers are drugs with different chemical properties and a common pharmacological characteristic. Calcium is very important in many physiological mechanisms and could be involved in neuronal damage following cerebral ischemia. Thus, calcium-channel blockers agents could be of interest in medical treatment of cerebrovascular diseases, headache and subarachnoid hemorrhage. Calcium-channel blockers seem to have a direct protective role against neuronal ischemic damage and/or a direct action on cerebral vessels. Some clinical experiences have suggested a protective role of nimodipine in the prevention of ischemic complications related to cerebral vasospasm after subarachnoid hemorrhage.
8-giu-1986
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
Italian
Con Impact Factor ISI
Nimodipine; Calcium Channel Blockers; Ischemic Attack, Transient; Subarachnoid Hemorrhage; Neurons; Blood-Brain Barrier; Brain Ischemia; Nicotinic Acids; Cerebrovascular Circulation; Humans
Govoni, S., Trabucchi, M.m., Battaini, F.m., Magnoni, M., Paoletti, R. (1986). [Vascular and neuronal mechanisms of calcium antagonists. Significance in neurological therapy]. MINERVA MEDICA, 77(24), 1053-1058.
Govoni, S; Trabucchi, Mm; Battaini, Fm; Magnoni, M; Paoletti, R
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55732
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