[3H]Nitrendipine bound to cerebral cortex membranes is displaced more efficiently by verapamil in old rats (24 months old) compared to young ones (3 months old). In addition, [3H]verapamil binding was studied in detail in 3-, 12- and 24-month-old rats. Aging increases the Bmax of [3H]verapamil, leaving the affinity unchanged. These observations further indicate that aging may affect calcium channels leading to a derangement of calcium movements which in turn alter neuronal activity.

Battaini, F.m., Govoni, S., Rius, R., Trabucchi, M.m. (1985). Age-dependent increase in [3H]verapamil binding to rat cortical membranes. NEUROSCIENCE LETTERS, 61(1-2), 67-71.

Age-dependent increase in [3H]verapamil binding to rat cortical membranes

BATTAINI, FIORENZO MARIA;TRABUCCHI, MARCO MARIO
1985-10-24

Abstract

[3H]Nitrendipine bound to cerebral cortex membranes is displaced more efficiently by verapamil in old rats (24 months old) compared to young ones (3 months old). In addition, [3H]verapamil binding was studied in detail in 3-, 12- and 24-month-old rats. Aging increases the Bmax of [3H]verapamil, leaving the affinity unchanged. These observations further indicate that aging may affect calcium channels leading to a derangement of calcium movements which in turn alter neuronal activity.
24-ott-1985
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore BIO/14 - FARMACOLOGIA
English
Con Impact Factor ISI
Ion Channels; Male; Membranes; Verapamil; Nitrendipine; Binding, Competitive; Rats; Animals; Calcium; Cerebral Cortex; Age Factors; Nifedipine; Rats, Inbred Strains; Aging
Battaini, F.m., Govoni, S., Rius, R., Trabucchi, M.m. (1985). Age-dependent increase in [3H]verapamil binding to rat cortical membranes. NEUROSCIENCE LETTERS, 61(1-2), 67-71.
Battaini, Fm; Govoni, S; Rius, R; Trabucchi, Mm
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/55681
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