OBJECTIVE: Children with recurrent upper-airway infections (UI) represent a social issue for their economic burden and negative impact on families. Bacteriotherapy is a new therapeutic strategy that could potentially prevent infections. The current study tested the hypothesis that recurrent UI may be prevented by bacteriotherapy.PATIENTS AND METHODS: This open study was conducted in an outpatient clinic, enrolling 80 children (40 males, mean age 5.26 +/- 2.52 years) suffering from recurrent UI. Children were treated with a nasal spray containing Streptococcus salivarius 24SMB and Streptococcus oralis 89a. 2 puffs per nostril twice a day for a week: this course was repeated for 3 months. The evaluated parameters were: number of UI and number of school and work absences: these outcomes were compared with those recorded in the past year.RESULTS: The mean number of UI significantly diminished: from 5.98 (2.30) in the past year to 2.75 (2.43) after treatment (p<0.0001). The number of school and work absences significantly diminished (from 4.50 +/- 2.81 to 2.80 +/- 3.42 and from 2.33 +/- 2.36 to 1.48 +/- 2.16 respectively: p<0.0001 for both).CONCLUSIONS: This preliminary experiment suggests that bacteriotherapy using Streptococcus salivarius 24SMB and Streptococcus oralis89a nasal spray could prevent recurrent UI in children.

Tarantino, V., Savaia, V., D'Agostino, R., Silvestri, M., Passali, F., Di Girolamo, S., et al. (2019). Bacteriotherapy in children with recurrent upper respiratory tract infections. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 23, 39-43 [10.26355/eurrev_201903_17347].

Bacteriotherapy in children with recurrent upper respiratory tract infections

Passali, FM;Di Girolamo, S;
2019-03-01

Abstract

OBJECTIVE: Children with recurrent upper-airway infections (UI) represent a social issue for their economic burden and negative impact on families. Bacteriotherapy is a new therapeutic strategy that could potentially prevent infections. The current study tested the hypothesis that recurrent UI may be prevented by bacteriotherapy.PATIENTS AND METHODS: This open study was conducted in an outpatient clinic, enrolling 80 children (40 males, mean age 5.26 +/- 2.52 years) suffering from recurrent UI. Children were treated with a nasal spray containing Streptococcus salivarius 24SMB and Streptococcus oralis 89a. 2 puffs per nostril twice a day for a week: this course was repeated for 3 months. The evaluated parameters were: number of UI and number of school and work absences: these outcomes were compared with those recorded in the past year.RESULTS: The mean number of UI significantly diminished: from 5.98 (2.30) in the past year to 2.75 (2.43) after treatment (p<0.0001). The number of school and work absences significantly diminished (from 4.50 +/- 2.81 to 2.80 +/- 3.42 and from 2.33 +/- 2.36 to 1.48 +/- 2.16 respectively: p<0.0001 for both).CONCLUSIONS: This preliminary experiment suggests that bacteriotherapy using Streptococcus salivarius 24SMB and Streptococcus oralis89a nasal spray could prevent recurrent UI in children.
mar-2019
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/31 - OTORINOLARINGOIATRIA
English
Con Impact Factor ISI
Recurrent upper-airway infections; Bacteriotherapy; Prevention; Streptococcus salivarius 24SMB; Streptococcus oralis 89a; Nasal spray; Children.
Tarantino, V., Savaia, V., D'Agostino, R., Silvestri, M., Passali, F., Di Girolamo, S., et al. (2019). Bacteriotherapy in children with recurrent upper respiratory tract infections. EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 23, 39-43 [10.26355/eurrev_201903_17347].
Tarantino, V; Savaia, V; D'Agostino, R; Silvestri, M; Passali, F; Di Girolamo, S; Ciprandi, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/218472
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