Memantine is an approved symptomatic treatment for moderate to severe Alzheimer's disease that reduces the excitotoxic effects of hyperactive glutamatergic transmission. However, the exact mechanism of the effect of memantine in Alzheimer's disease patients is poorly understood. Importantly, the default mode network (DMN), which plays a key role in attention, is hypoactive in Alzheimer's disease and is under glutamatergic control.

Lorenzi, M., Beltramello, A., Mercuri, N.b., Canu, E., Zoccatelli, G., Pizzini, F., et al. (2011). Effect of memantine on resting state default mode network activity in Alzheimer's disease. DRUGS & AGING, 28(3), 205-217 [10.2165/11586440-000000000-00000].

Effect of memantine on resting state default mode network activity in Alzheimer's disease

MERCURI, NICOLA BIAGIO;CALTAGIRONE, CARLO;
2011-03-01

Abstract

Memantine is an approved symptomatic treatment for moderate to severe Alzheimer's disease that reduces the excitotoxic effects of hyperactive glutamatergic transmission. However, the exact mechanism of the effect of memantine in Alzheimer's disease patients is poorly understood. Importantly, the default mode network (DMN), which plays a key role in attention, is hypoactive in Alzheimer's disease and is under glutamatergic control.
1-mar-2011
Pubblicato
Rilevanza internazionale
Articolo
Sì, ma tipo non specificato
Settore MED/26 - NEUROLOGIA
English
Magnetic Resonance Imaging; Humans; Alzheimer Disease; Brain; Rest; Memantine; Aged; Neuropsychological Tests; Male; Female
Lorenzi, M., Beltramello, A., Mercuri, N.b., Canu, E., Zoccatelli, G., Pizzini, F., et al. (2011). Effect of memantine on resting state default mode network activity in Alzheimer's disease. DRUGS & AGING, 28(3), 205-217 [10.2165/11586440-000000000-00000].
Lorenzi, M; Beltramello, A; Mercuri, Nb; Canu, E; Zoccatelli, G; Pizzini, F; Alessandrini, F; Cotelli, M; Rosini, S; Costardi, D; Caltagirone, C; Frisoni, G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/99558
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