Aim of our study was to investigate the different effects on attentional capacity of deep brain stimulation DBS (STN or GPi) and of l-dopa in PD patients. Patients were evaluated on-DBS/off-l-dopa, on-l-dopa/off-DBS, on-l-dopa/on-DBS and off-l-dopa/off-DBS. Our results indicate that DBS effects on attentional functions parallel those of l-dopa. A site independent (both STN and GPi) worsening of verbal fluency was observed, possibly connected to the stimulus effect on the cortico-subcortical-cortical loop.
Brusa, L., Pierantozzi, M., Peppe, A., Altibrandi, M., Giacomini, P., Mazzone, P., et al. (2001). Deep brain stimulation (DBS) attentional effects parallel those of l-dopa treatment. JOURNAL OF NEURAL TRANSMISSION, 108(8-9), 1021-1027.
Deep brain stimulation (DBS) attentional effects parallel those of l-dopa treatment
PIERANTOZZI, MARIANGELA;GIACOMINI, PIERGIORGIO;STANZIONE, PAOLO
2001-01-01
Abstract
Aim of our study was to investigate the different effects on attentional capacity of deep brain stimulation DBS (STN or GPi) and of l-dopa in PD patients. Patients were evaluated on-DBS/off-l-dopa, on-l-dopa/off-DBS, on-l-dopa/on-DBS and off-l-dopa/off-DBS. Our results indicate that DBS effects on attentional functions parallel those of l-dopa. A site independent (both STN and GPi) worsening of verbal fluency was observed, possibly connected to the stimulus effect on the cortico-subcortical-cortical loop.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
