Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities: when in the off treatment condition, when on pramipexole, and when on l-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while l-dopa did not. Moreover, pramipexole opposite to l-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.
Brusa, L., Bassi, A., Stefani, A., Pierantozzi, M., Peppe, A., Caramia, M., et al. (2003). Pramipexole in comparison to l-dopa: a neuropsychological study. JOURNAL OF NEURAL TRANSMISSION, 110(4), 373-380 [10.1007/s00702-002-0811-7].
Pramipexole in comparison to l-dopa: a neuropsychological study
STEFANI, ALESSANDRO;PIERANTOZZI, MARIANGELA;Caramia, M;STANZIONE, PAOLO
2003-04-01
Abstract
Twenty right-handed patients affected by early/mild Parkinson's disease were evaluated in a randomised study using neuropsychological and clinical assessements during three treatment modalities: when in the off treatment condition, when on pramipexole, and when on l-dopa. In comparison to the off treatment condition, the DA-agonist pramipexole produced a significant impairment of short term verbal memory, attentional-executive functions and verbal fluency, while l-dopa did not. Moreover, pramipexole opposite to l-dopa, failed to improve FAS and Stroop tests. Present findings indicate that pramipexole may worsen cognitive functions although not exceeding normative values.File | Dimensione | Formato | |
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