Entacapone is a COMT inhibitor used in Parkinson's disease (PD) patients, as an adjunctive therapy to L-dopa in order to prolong its bioavailability and thus its clinical effect. However, previous studies reported entacapone-induced L-dopa to have lower C(max) and delayed t(max) values, coupled with a delayed onset of the clinical effect, possibly suggesting an interference between the two drugs. The aim of our study was to evaluate whether a delayed entacapone administration in association with standard L-dopa/carbidopa, may in some subjects improve the entacapone effects on L-dopa AUC and thus on the clinical 'on time' duration.

Brusa, L., Bassi, A., Lunardi, G., Fedele, E., Peppe, A., Stefani, A., et al. (2004). Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug. EUROPEAN JOURNAL OF NEUROLOGY, 11(9), 593-606 [10.1111/j.1468-1331.2004.00860.x].

Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug

STEFANI, ALESSANDRO;STANZIONE, PAOLO;PIERANTOZZI, MARIANGELA
2004-09

Abstract

Entacapone is a COMT inhibitor used in Parkinson's disease (PD) patients, as an adjunctive therapy to L-dopa in order to prolong its bioavailability and thus its clinical effect. However, previous studies reported entacapone-induced L-dopa to have lower C(max) and delayed t(max) values, coupled with a delayed onset of the clinical effect, possibly suggesting an interference between the two drugs. The aim of our study was to evaluate whether a delayed entacapone administration in association with standard L-dopa/carbidopa, may in some subjects improve the entacapone effects on L-dopa AUC and thus on the clinical 'on time' duration.
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/26 - Neurologia
English
Catechols; Drug Interactions; Levodopa; Area Under Curve; Double-Blind Method; Humans; Carbidopa; Aged; Antiparkinson Agents; Drug Resistance; Chromatography, High Pressure Liquid; Biological Availability; Nitriles; Parkinson Disease; Middle Aged; Male; Female
Brusa, L., Bassi, A., Lunardi, G., Fedele, E., Peppe, A., Stefani, A., et al. (2004). Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug. EUROPEAN JOURNAL OF NEUROLOGY, 11(9), 593-606 [10.1111/j.1468-1331.2004.00860.x].
Brusa, L; Bassi, A; Lunardi, G; Fedele, E; Peppe, A; Stefani, A; Pasqualetti, P; Stanzione, P; Pierantozzi, M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2108/99455
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