Previous studies suggested that the hypo-activity of the external pallidus (GPe) might drive the hyper-activity of subthalamic neurons, which underlies the cardinal symptoms of Parkinson's disease. We have challenged this view, based on the so-called 'indirect pathway', by recording apomorphine effects from both structures of parkinsonian patients, at rest and during passive movements.
Stefani, A., Bassi, A., Mazzone, P., Pierantozzi, M., Gattoni, G., Altibrandi, M., et al. (2002). Subdyskinetic apomorphine responses in globus pallidus and subthalamus of parkinsonian patients: lack of clear evidence for the 'indirect pathway'. CLINICAL NEUROPHYSIOLOGY, 113(1), 91-100.
Subdyskinetic apomorphine responses in globus pallidus and subthalamus of parkinsonian patients: lack of clear evidence for the 'indirect pathway'
STEFANI, ALESSANDRO;PIERANTOZZI, MARIANGELA;GATTONI, GIUSEPPE;BERNARDI, GIORGIO;STANZIONE, PAOLO
2002-01-01
Abstract
Previous studies suggested that the hypo-activity of the external pallidus (GPe) might drive the hyper-activity of subthalamic neurons, which underlies the cardinal symptoms of Parkinson's disease. We have challenged this view, based on the so-called 'indirect pathway', by recording apomorphine effects from both structures of parkinsonian patients, at rest and during passive movements.| File | Dimensione | Formato | |
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