Oxacillin-resistant staphylococci are the most serious pathogens in chronic osteomyelitis and only glycopeptides have been shown to be efficacious against them. We assessed the safety and efficacy of a regimen of teicoplanin 400 mg/day i.m. as long-term treatment in outpatients with osteomyelitis. A total of 76 patients received teicoplanin. Twenty-five patients had chronic prosthetic osteomyelitis (20 hip) and 51 patients had osteomyelitis caused by osteo-syn-thesis devices. Oxacillin-resistant Staphylococcus aureus was isolated in pure culture in 55 patients (72%). A total of 21 patients had polymicrobial infection with a total of 48 isolated strains. All patients were treated with teicoplanin 400 mg i.m. once-a-day alone or with other drugs for a minimum of 4 months. Only one patient had side effects requiring discontinuation of treatment. The teicoplanin dose was reduced to 200 mg/day i.m. in 2 patients to decrease cre-atinine clearance values. Seventy out of 76 patients were cured.

Testore, G.p., Uccella, I., Sarrecchia, C., Mattei, A., Impagliazzo, A., Sordillo, P., et al. (2000). Long-term intramuscular teicoplanin treatment of chronic osteomyelitis due to oxacillin-resistant Staphylococcus aureus in outpatients. JOURNAL OF CHEMOTHERAPY, 12(5), 412-415.

Long-term intramuscular teicoplanin treatment of chronic osteomyelitis due to oxacillin-resistant Staphylococcus aureus in outpatients

TESTORE, GIAN PIERO;SARRECCHIA, CESARE;SORDILLO, PASQUALE;ANDREONI, MASSIMO
2000-01-01

Abstract

Oxacillin-resistant staphylococci are the most serious pathogens in chronic osteomyelitis and only glycopeptides have been shown to be efficacious against them. We assessed the safety and efficacy of a regimen of teicoplanin 400 mg/day i.m. as long-term treatment in outpatients with osteomyelitis. A total of 76 patients received teicoplanin. Twenty-five patients had chronic prosthetic osteomyelitis (20 hip) and 51 patients had osteomyelitis caused by osteo-syn-thesis devices. Oxacillin-resistant Staphylococcus aureus was isolated in pure culture in 55 patients (72%). A total of 21 patients had polymicrobial infection with a total of 48 isolated strains. All patients were treated with teicoplanin 400 mg i.m. once-a-day alone or with other drugs for a minimum of 4 months. Only one patient had side effects requiring discontinuation of treatment. The teicoplanin dose was reduced to 200 mg/day i.m. in 2 patients to decrease cre-atinine clearance values. Seventy out of 76 patients were cured.
2000
Pubblicato
Rilevanza internazionale
Articolo
Esperti anonimi
Settore MED/17 - MALATTIE INFETTIVE
English
Con Impact Factor ISI
Oxacillin-Resistant Staphylococcus aureus; teicoplanin;osteomyelitis;
Testore, G.p., Uccella, I., Sarrecchia, C., Mattei, A., Impagliazzo, A., Sordillo, P., et al. (2000). Long-term intramuscular teicoplanin treatment of chronic osteomyelitis due to oxacillin-resistant Staphylococcus aureus in outpatients. JOURNAL OF CHEMOTHERAPY, 12(5), 412-415.
Testore, Gp; Uccella, I; Sarrecchia, C; Mattei, A; Impagliazzo, A; Sordillo, P; Andreoni, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2108/99317
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